Volume 9, Issue 1 (3-2024)
J Res Dent Maxillofac Sci 2024, 9(1): 35-42 |
Back to browse issues page
Ethics code: IR. SUMS.RCC.1397.519
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Azad A, Haghnegahdar A, Ghapanchi J, Hakimelahi A, Mansouri Z. Panoramic Radiographic Features of Patients with Acute Leukemia and Lymphoma who Are Candidates for Hematopoietic Stem Cell Transplantation. J Res Dent Maxillofac Sci 2024; 9 (1) :35-42
URL: http://jrdms.dentaliau.ac.ir/article-1-513-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-513-en.html
1- Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
3- Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4- Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , mansouriz9085@gmail.com
2- Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
3- Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
4- Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , mansouriz9085@gmail.com
Abstract: (214 Views)
Background and Aim: Hematopoietic malignancies like leukemia and lymphoma may present several complications. This study aimed to evaluate the panoramic radiographic features of patients with acute leukemia and lymphoma who are candidates for hematopoietic stem cell transplantation (HSCT).
Materials and Methods: In this cross-sectional study, 63 panoramic radiographs of HSCT candidates (25 females, 38 males, between 16-75 years) and 62 healthy individuals (25 females, 37 males, between 16-73 years) were evaluated in Shiraz, Iran. Osteoporosis, pathological radiolucencies, pathological calcifications, cortical bone thickness, periodontal disease, condylar degeneration, and other alveolar bone findings were recorded. Data were analyzed by the Chi-square, Fisher’s exact, and Mann-Whitney U tests (alpha=0.05).
Results: The thickness of nasal floor cortical bone, mandibular inferior cortex, and mandibular canal cortex was significantly lower in the patient group than the healthy group (P<0.05). Other abnormalities such as changes in periodontal ligament width, lamina dura thickness, and condylar degeneration were also more prevalent in HSCT patients compared to healthy controls (P≤0.05).
Conclusion: It appears that panoramic views provide reliable information for detection of osteopenia and osteoporosis in HSCT patients. This may reduce the use of expensive and invasive diagnostic workups with radiation exposure to detect low bone density in this group of compromised patients.
Materials and Methods: In this cross-sectional study, 63 panoramic radiographs of HSCT candidates (25 females, 38 males, between 16-75 years) and 62 healthy individuals (25 females, 37 males, between 16-73 years) were evaluated in Shiraz, Iran. Osteoporosis, pathological radiolucencies, pathological calcifications, cortical bone thickness, periodontal disease, condylar degeneration, and other alveolar bone findings were recorded. Data were analyzed by the Chi-square, Fisher’s exact, and Mann-Whitney U tests (alpha=0.05).
Results: The thickness of nasal floor cortical bone, mandibular inferior cortex, and mandibular canal cortex was significantly lower in the patient group than the healthy group (P<0.05). Other abnormalities such as changes in periodontal ligament width, lamina dura thickness, and condylar degeneration were also more prevalent in HSCT patients compared to healthy controls (P≤0.05).
Conclusion: It appears that panoramic views provide reliable information for detection of osteopenia and osteoporosis in HSCT patients. This may reduce the use of expensive and invasive diagnostic workups with radiation exposure to detect low bone density in this group of compromised patients.
Type of Study: Original article |
Subject:
Oral medicine
References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Prakash G, Kaur A, Malhotra P, Khadwal A, Sharma P, Suri V, Varma N, Varma S. Current Role of Genetics in Hematologic Malignancies. Indian J Hematol Blood Transfus. 2016 Mar;32(1):18-31. [DOI:10.1007/s12288-015-0584-4] [PMID] []
3. Shahnazi M, Khatami A, Shamsian B, Haerizadeh B, Mehrafarin M. Bony lesions in pediatric acute leukemia: pictorial essay. Iran J Radiol. 2012 Mar;9(1):50-6. [DOI:10.5812/iranjradiol.6765] [PMID] []
4. Barbosa CM, Nakamura C, Terreri MT, Lee ML, Petrilli AS, Hilário MO. Manifestações músculo-esqueléticas como apresentação inicial das leucemias agudas na infância [Musculoskeletal manifestations as the onset of acute leukemias in childhood]. J Pediatr (Rio J). 2002 Nov-Dec;78(6):481-4. [DOI:10.1590/S0021-75572002000600007]
5. Prasad SR, Anitha, Jayaram R, Pai A, Yaji AY, Jambunath U, et al. Oral manifestations of myeloid neoplasms and acute leukemia- a diagnostic perspective. Hematol Transfus Int J . 2018;6(5):177-80. [DOI:10.15406/htij.2018.06.00177]
6. Kim SH, Lim SK, Hahn JS. Effect of pamidronate on new vertebral fractures and bone mineral density in patients with malignant lymphoma receiving chemotherapy. Am J Med. 2004 Apr 15;116(8):524-8. [DOI:10.1016/j.amjmed.2003.12.019] [PMID]
7. Le Meignen M, Auquier P, Barlogis V, Sirvent N, Contet A, Simeoni MC, Galambrun C, Poirée M, Chastagner P, Play B, Villes V, Berbis J, Chambost H, Bordigoni P, Michel G. Bone mineral density in adult survivors of childhood acute leukemia: impact of hematopoietic stem cell transplantation and other treatment modalities. Blood. 2011 Aug 11;118(6):1481-9. [DOI:10.1182/blood-2011-01-332866] [PMID]
8. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ; American Cancer Society. Cancer statistics, 2004. CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29. [DOI:10.3322/canjclin.54.1.8] [PMID]
9. Zahid U, Akbar F, Amaraneni A, Husnain M, Chan O, Riaz IB, McBride A, Iftikhar A, Anwer F. A Review of Autologous Stem Cell Transplantation in Lymphoma. Curr Hematol Malig Rep. 2017 Jun;12(3):217-26. [DOI:10.1007/s11899-017-0382-1] [PMID] []
10. Melkos AB, Massenkeil G, Arnold R, Reichart PA. Dental treatment prior to stem cell transplantation and its influence on the posttransplantation outcome. Clin Oral Investig. 2003 Jun;7(2):113-5. [DOI:10.1007/s00784-003-0209-4] [PMID]
11. Elad S, Garfunkel AA, Or R, Michaeli E, Shapira MY, Galili D. Time limitations and the challenge of providing infection-preventing dental care to hematopoietic stem-cell transplantation patients. Support Care Cancer. 2003 Oct;11(10):674-7. [DOI:10.1007/s00520-003-0499-8] [PMID]
12. Guggenheimer J, Eghtesad B, Stock DJ. Dental management of the (solid) organ transplant patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Apr;95(4):383-9. [DOI:10.1067/moe.2003.150] [PMID]
13. Donker AE, van Merkesteyn JP, Bredius RG, van Weel-Sipman MH. Value of panoramic radiographs in paediatric pre-bone marrow transplantation oral evaluation. Int J Oral Maxillofac Surg. 2002 Apr;31(2):170-2. [DOI:10.1054/ijom.2001.0200] [PMID]
14. Sutter W, Berger S, Meier M, Kropp A, Kielbassa AM, Turhani D. Cross-sectional study on the prevalence of carotid artery calcifications, tonsilloliths, calcified submandibular lymph nodes, sialoliths of the submandibular gland, and idiopathic osteosclerosis using digital panoramic radiography in a Lower Austrian subpopulation. Quintessence Int. 2018 Jan 22:231-42.
15. Choi JW. Assessment of panoramic radiography as a national oral examination tool: review of the literature. Imaging Sci Dent. 2011 Mar;41(1):1-6. [DOI:10.5624/isd.2011.41.1.1] [PMID] []
16. Frascino AV, Costa C, Salgado DMRA, Coracin FL, Fava M, Odone-Filho V. Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation. Clinics (Sao Paulo). 2019;74:e929. [DOI:10.6061/clinics/2019/e929] [PMID] []
17. Calciolari E, Donos N, Park JC, Petrie A, Mardas N. Panoramic measures for oral bone mass in detecting osteoporosis: a systematic review and meta-analysis. J Dent Res. 2015 Mar;94(3 Suppl):17S-27S. [DOI:10.1177/0022034514554949] [PMID] []
18. Ghapanchi J, Zahed M, Haghnegahdar A, Niakan N, Sadeghzadeh A. Osteoporosis and Jaw Abnormalities in Panoramic Radiography of Chronic Liver Failure Patients. Biomed Res Int. 2018 Aug 26;2018:4280312. [DOI:10.1155/2018/4280312] [PMID] []
19. Avril L, Lombardi T, Ailianou A, Burkhardt K, Varoquaux A, Scolozzi P, Becker M. Radiolucent lesions of the mandible: a pattern-based approach to diagnosis. Insights Imaging. 2014 Feb;5(1):85-101. [DOI:10.1007/s13244-013-0298-9] [PMID] []
20. Bäck K, Ahlqwist M, Hakeberg M, Dahlström L. Occurrence of signs of osteoarthritis/arthrosis in the temporomandibular joint on panoramic radiographs in Swedish women. Community Dent Oral Epidemiol. 2017 Oct;45(5):478-84. [DOI:10.1111/cdoe.12312] [PMID]
21. Tolentino Ede S, Gusmão PH, Cardia GS, Tolentino Lde S, Iwaki LC, Amoroso-Silva PA. Idiopathic Osteosclerosis of the Jaw in a Brazilian Population: a Retrospective Study. Acta Stomatol Croat. 2014 Sep;48(3):183-92. [DOI:10.15644/asc48/3/2] [PMID] []
22. Khaddour K, Hana CK, Mewawalla P. Hematopoietic stem cell transplantation. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.
23. Frick M, Chan W, Arends CM, Hablesreiter R, Halik A, Heuser M, et al. Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation. J Clin Oncol. 2019 Feb 10;37(5):375-85. [DOI:10.1200/JCO.2018.79.2184] [PMID]
24. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ; American Cancer Society. Cancer statistics, 2004. CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29. [DOI:10.3322/canjclin.54.1.8] [PMID]
25. Lim LZ, Padilla RJ, Reside GJ, Tyndall DA. Comparing panoramic radiographs and cone beam computed tomography: Impact on radiographic features and differential diagnoses. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Apr 17:S2212-4403(18)30888-5.
26. Neves FS, Nascimento MC, Oliveira ML, Almeida SM, Bóscolo FN. Comparative analysis of mandibular anatomical variations between panoramic radiography and cone beam computed tomography. Oral Maxillofac Surg. 2014 Dec;18(4):419-24. [DOI:10.1007/s10006-013-0428-z] [PMID]
27. Kim OS, Shin MH, Song IH, Lim IG, Yoon SJ, Kim OJ, Lee YH, Kim YJ, Chung HJ. Digital panoramic radiographs are useful for diagnosis of osteoporosis in Korean postmenopausal women. Gerodontology. 2016 Jun;33(2):185-92. [DOI:10.1111/ger.12134] [PMID]
28. Curtis AB. Childhood leukemias: osseous changes in jaws on panoramic dental radiographs. J Am Dent Assoc. 1971 Oct;83(4):844-7. [DOI:10.14219/jada.archive.1971.0405] [PMID]
29. O'Shaughnessy PE. Chronic lymphatic leukemia suggestive of multiple myeloma: Report of a case. Oral Surg Oral Med Oral Pathol. 1964 Feb;17:170-4. [DOI:10.1016/0030-4220(64)90136-7] [PMID]
30. Kosugi K, Yonezu H, Kawashima S, Honda K, Arai Y, Shibahara T. A longitudinal study of the effect of experimental osteoporosis on bone trabecular structure in the rat mandibular condyle. Cranio. 2013 Apr;31(2):140-50. [DOI:10.1179/crn.2013.022] [PMID]
31. Cevidanes LH, Walker D, Schilling J, Sugai J, Giannobile W, Paniagua B, et al. 3D osteoarthritic changes in TMJ condylar morphology correlates with specific systemic and local biomarkers of disease. Osteoarthritis Cartilage. 2014 Oct;22(10):1657-67. [DOI:10.1016/j.joca.2014.06.014] [PMID] []
32. Lv X, Li Q, Wu S, Sun J, Zhang M, Chen YJ. Psychological stress alters the ultrastructure and increases IL-1β and TNF-α in mandibular condylar cartilage. Braz J Med Biol Res. 2012 Oct;45(10):968-76. [DOI:10.1590/S0100-879X2012007500102] [PMID] []
33. Moshfeghi M, Azimi F, Anvari M. Radiologic assessment and frequency of idiopathic osteosclerosis of jawbones: an interpopulation comparison. Acta Radiol. 2014 Dec;55(10):1239-44. [DOI:10.1177/0284185113515210] [PMID]
34. Fuentes R, Arias A, Astete N, Farfán C, Garay I, Dias F. Prevalence and morphometric analysis of idiopathic osteosclerosis in a Chilean population. Folia Morphol (Warsz). 2018;77(2):272-8. [DOI:10.5603/FM.a2017.0085] [PMID]
35. Takahashi A, Sugawara C, Kudoh T, Ohe G, Takamaru N, Tamatani T, Nagai H, Miyamoto Y. Prevalence and imaging characteristics of palatine tonsilloliths evaluated on 2244 pairs of panoramic radiographs and CT images. Clin Oral Investig. 2017 Jan;21(1):85-91. [DOI:10.1007/s00784-016-1752-0] [PMID]
36. Overholser CD, Peterson DE, Williams LT, Schimpff SC. Periodontal infection in patients with acute nonlymphocyte leukemia. Prevalence of acute exacerbations. Arch Intern Med. 1982 Mar;142(3):551-4. [DOI:10.1001/archinte.142.3.551] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
