Volume 8, Issue 1 (1-2023)
J Res Dent Maxillofac Sci 2023, 8(1): 62-70 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Gholami M, Asadinejad S M, Kakavand D, Jafari Doudaran P, Fathi A H. Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies. J Res Dent Maxillofac Sci 2023; 8 (1) :62-70
URL: http://jrdms.dentaliau.ac.ir/article-1-397-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-397-en.html
Mahnaz Gholami1 
, Seyedeh Mohadeseh Asadinejad2 , Delara Kakavand3 , Pooya Jafari Doudaran4 , Amir Hossein Fathi * 
5
, Seyedeh Mohadeseh Asadinejad2 , Delara Kakavand3 , Pooya Jafari Doudaran4 , Amir Hossein Fathi * 5
1- Department of Periodontics, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Periodontics, School of Dentistry, Isfahan University of Medi-cal Sciences, Isfahan, Iran
3- Dental Clinic, Mazandaran University of Medical Sciences, Sari, Iran
4- Student Research Committee, Qom University of Medical Sciences, Qom, Iran
5- Dental Material Research Center and Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran ,farhad20091367@gmail.com
2- Department of Periodontics, School of Dentistry, Isfahan University of Medi-cal Sciences, Isfahan, Iran
3- Dental Clinic, Mazandaran University of Medical Sciences, Sari, Iran
4- Student Research Committee, Qom University of Medical Sciences, Qom, Iran
5- Dental Material Research Center and Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract: (1327 Views)
| Background and Aim: Periodontitis, as the most prevalent cause of tooth loss, affects 20-50% of individuals throughout the world. One factor involved in the severity and incidence of periodontitis is aging, which is a substantial risk factor for mortality and morbidity. It is stated that some disorders are common in older population, like cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease. Understanding the changes related to aging may provide a better insight into age-related diseases. Hence, this study aimed to review and summarize evidence regarding periodontitis and aging-related disorders with a mechanistic insight. Materials and Methods: Data were obtained from the scientific databases, including PubMed, Google Scholar, and Scopus in English between 1993 and 2021. Results: Cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease are associated with periodontitis directly or indirectly, and pro-inflammatory cytokines are the key mediators in such relationships. For instance, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 have a substantial role in pathogenesis of periodontitis in the majority of such diseases. These agents, particularly IL-1β and TNF-α, can also lead to leukocyte migration and subsequently form reactive oxygen species (ROS), reactive nitrogen species, and matrix metalloproteinases (MMPs). Conclusion: It seems that periodontitis is linked to aging-related diseases, namely cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease by the mediation of pro-inflammatory agents such as IL-1β, TNF-α, and IL-6. |
Type of Study: Review article |
Subject:
Periodontology
References
1. Cecoro G, Annunziata M, Iuorio MT, Nastri L, Guida L. Periodontitis, Low-Grade Inflammation and Systemic Health: A Scoping Review. Medicina (Kaunas). 2020;56(6):272. [DOI:10.3390/medicina56060272] [PMID] [PMCID]
2. Johnson A, Kong F, Miao S, Thomas S, Ansar S, Kong ZL. In-Vitro Antibacterial and Anti-Inflammatory Effects of Surfactin-Loaded Nanoparticles for Periodontitis Treatment. Nanomaterials (Basel). 2021;11(2):356. [DOI:10.3390/nano11020356] [PMID] [PMCID]
3. Dietrich T, Garcia RI. Associations between periodontal disease and systemic disease: evaluating the strength of the evidence. J Periodontol. 2005;76(11 Suppl):2175-84. [DOI:10.1902/jop.2005.76.11-S.2175]
4. Xu Q, Liu Z, Guo L, Liu R, Li R, Chu X, et al. Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells. Mol Cells. 2019;42(11):763-72.
5. Cheng R, Wu Z, Li M, Shao M, Hu T. Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review. Int J Oral Sci. 2020;12(1):2. [DOI:10.1038/s41368-019-0068-8] [PMID] [PMCID]
6. Teng F, Darveekaran Nair SS, Zhu P, Li S, Huang S, Li X, et al. Impact of DNA extraction method and targeted 16S-rRNA hypervariable region on oral microbiota profiling. Sci Rep. 2018;8(1):16321. [DOI:10.1038/s41598-018-34294-x] [PMID] [PMCID]
7. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997;14:9-11. [DOI:10.1111/j.1600-0757.1997.tb00189.x] [PMID]
8. Dharshini D. Pro-Inflammatory Mediators In Periodontal Disease-Review Article. European Journal of Molecular & Clinical Medicine. 2020; 7 (8):1856-64.
9. Ebersole JL, Al-Sabbagh M, Dawson DR 3rd. Heterogeneity of human serum antibody responses to P. gingivalis in periodontitis: Effects of age, race/ethnicity, and sex. Immunol Lett. 2020; 218: 11-21. [DOI:10.1016/j.imlet.2019.12.004] [PMID] [PMCID]
10. Warraich UE, Hussain F, Kayani HUR. Aging - Oxidative stress, antioxidants and computational modeling. Heliyon. 2020;6(5):e04107. [DOI:10.1016/j.heliyon.2020.e04107] [PMID] [PMCID]
11. Clark D, Kotronia E, Ramsay SE. Frailty, aging, and periodontal disease: Basic biologic considerations. Periodontol 2000. 2021;87(1):143-56. [DOI:10.1111/prd.12380] [PMID] [PMCID]
12. Kahleova H, Levin S, Barnard ND. Plant-Based Diets for Healthy Aging. J Am Coll Nutr. 2021; 40 (5):478-9. [DOI:10.1080/07315724.2020.1790442] [PMID]
13. Chen S, Li Y, Zhi S, Ding Z, Huang Y, Wang W, et al. lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis. Aging Dis. 2020;11(5):1058-68. [DOI:10.14336/AD.2019.0724] [PMID] [PMCID]
14. O'Hare AM, Choi AI, Bertenthal D, Bacchetti P, Garg AX, Kaufman JS, et al. Age affects outcomes in chronic kidney disease. J Am Soc Nephrol. 2007; 18 (10):2758-65. [DOI:10.1681/ASN.2007040422] [PMID]
15. Gil L, Niño SA, Capdeville G, Jiménez-Capdeville ME. Aging and Alzheimer's disease connection: Nuclear Tau and lamin A. Neurosci Lett. 2021; 749: 135741. [DOI:10.1016/j.neulet.2021.135741] [PMID]
16. Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017;11(2):72-80.
17. Van Dyke TE, Sheilesh D. Risk factors for periodontitis. J Int Acad Periodontol. 2005;7(1):3-7.
18. Hart TC, Kornman KS. Genetic factors in the pathogenesis of periodontitis. Periodontol 2000. 1997;14:202-15. [DOI:10.1111/j.1600-0757.1997.tb00198.x] [PMID]
19. Ramadan DE, Hariyani N, Indrawati R, Ridwan RD, Diyatri I. Cytokines and Chemokines in Periodontitis. Eur J Dent. 2020;14(3):483-95. [DOI:10.1055/s-0040-1712718] [PMID] [PMCID]
20. Yucel-Lindberg T, Båge T. Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med. 2013;15:e7. [DOI:10.1017/erm.2013.8] [PMID]
21. Motedayyen H, Ghotloo S, Saffari M, Sattari M, Amid R. Evaluation of MicroRNA-146a and Its Targets in Gingival Tissues of Patients With Chronic Periodontitis. J Periodontol. 2015;86(12):1380-5. [DOI:10.1902/jop.2015.150319] [PMID]
22. Waddington RJ, Moseley R, Embery G. Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases. Oral Dis. 2000;6(3):138-51. [DOI:10.1111/j.1601-0825.2000.tb00325.x] [PMID]
23. Dahiya P, Kamal R, Gupta R, Bhardwaj R, Chaudhary K, Kaur S. Reactive oxygen species in periodontitis. J Indian Soc Periodontol. 2013; 17 (4):411-6. [DOI:10.4103/0972-124X.118306] [PMID] [PMCID]
24. Tomar SL, Asma S. Smoking-Attributable Periodontitis in the United States: Findings From NHANES III. J Periodontol. 2000;71(5):743-51. [DOI:10.1902/jop.2000.71.5.743]
25. Wimmer G, Janda M, Wieselmann-Penkner K, Jakse N, Polansky R, Pertl C. Coping with stress: its influence on periodontal disease. J Periodontol. 2002;73(11):1343-51. [DOI:10.1902/jop.2002.73.11.1343] [PMID]
26. Houri-Haddad Y, Itzchaki O, Ben-Nathan D, Shapira L. The effect of chronic emotional stress on the humoral immune response to Porphyromonas gingivalis in mice. J Periodontal Res. 2003; 38(2): 204-9. [DOI:10.1034/j.1600-0765.2003.20390.x] [PMID]
27. Castro GD, Oppermann RV, Haas AN, Winter R, Alchieri JC. Association between psychosocial factors and periodontitis: a case-control study. J Clin Periodontol. 2006;33(2):109-14. [DOI:10.1111/j.1600-051X.2005.00878.x] [PMID]
28. Solis AC, Lotufo RF, Pannuti CM, Brunheiro EC, Marques AH, Lotufo-Neto F. Association of periodontal disease to anxiety and depression symptoms, and psychosocial stress factors. J Clin Periodontol. 2004;31(8):633-8. [DOI:10.1111/j.1600-051X.2004.00538.x] [PMID]
29. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A. 2003; 100 (15):9090-5. [DOI:10.1073/pnas.1531903100] [PMID] [PMCID]
30. Chai L, Song YQ, Leung WK. Genetic polymorphism studies in periodontitis and Fcγ receptors. J Periodontal Res. 2012;47(3):273-85. [DOI:10.1111/j.1600-0765.2011.01437.x] [PMID]
31. Deas DE, Mackey SA, McDonnell HT. Systemic disease and periodontitis: manifestations of neutrophil dysfunction. Periodontol 2000. 2003;32: 82-104. [DOI:10.1046/j.0906-6713.2003.03207.x] [PMID]
32. Millard HR, Musani SK, Dibaba DT, Talegawkar SA, Taylor HA, Tucker KL, Bidulescu A. Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study. Eur J Nutr. 2018; 57(1):51-60.
33. Roghani-Shahraki H, Karimian M, Valipour S, Behjati M, Arefnezhad R, Mousavi A. Herbal therapy as a promising approach for regulation on lipid profiles: A review of molecular aspects. J Cell Physiol. 2021;236(8):5533-46.
34. Demmer RT, Desvarieux M. Periodontal infections and cardiovascular disease: the heart of the matter. J Am Dent Assoc. 2006;137 Suppl:14S-20S; quiz 38S. [DOI:10.14219/jada.archive.2006.0402] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
