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Volume 11, Issue 1 (3-2026)                   J Res Dent Maxillofac Sci 2026, 11(1): 84-96 | Back to browse issues page


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Kiani K, Saligheh Rad M, Azizi A, Ghods K. The Role of Nanobots Along with Artificial Intelligence in Dentistry: A Comprehensive Review on Applications, Advancements, and Future Prospects. J Res Dent Maxillofac Sci 2026; 11 (1) :84-96
URL: http://jrdms.dentaliau.ac.ir/article-1-1035-en.html
1- Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2- Oral Medicine Department, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3- Dental Material Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran , kimiaghods2@gmail.com
Abstract:   (297 Views)
Background and Aim: Nanotechnology has revolutionized dentistry with the introduction of nanobots. These microscopic devices have shown promising applications in diagnosis, treatment, and preventive dental care. The aim of this study was to explore the diverse applications of nanobots along with artificial intelligence (AI) in different dental specialties, highlighting their advantages, limitations, and future potential.   
Materials and Methods: For this comprehensive literature review, a complete query was carried out in PubMed, Google Scholar, Embase, and Scopus databases, and the studies published during 2010-2025 were collected using the keywords "Nanotechnology," "Dentistry," "Robotics," "Nanoparticles," and "Dental Materials." After applying appropriate inclusion and exclusion criteria, 113 English articles were selected and evaluated.   
Results: Nanobots demonstrate significant potential across various dental disciplines. In endodontics, they enhance root canal disinfection; while, in periodontics, they facilitate biofilm disruption and tissue regeneration. Restorative dentistry benefits from their integration into filling materials, improving durability and functionality. Orthodontic applications include precisely guided tooth movements and real-time monitoring of the periodontal environment. In oral surgery, nanobots enable precise tissue manipulation and accelerated wound healing. Furthermore, they offer promising capabilities for early diagnosis and targeted drug delivery systems in oral medicine.
Conclusion: Nanobots hold transformative potential in various dental disciplines, offering innovative solutions for improved diagnosis, treatment precision, and patient care. However, further research is needed to address safety concerns, regulatory approvals, ethical issues, and cost-effectiveness before clinical integration. Advancements in nanotechnology and AI may pave the way for the widespread use of nanobots, revolutionizing modern dental practice
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Type of Study: Review article | Subject: Oral medicine

References
1. Bhatt P, Kumar A, Shukla R. Nanorobots recent and future advances in cancer or dentistry therapy-A review. Am J PharmTech Res. 2019 Jun;9(3):321-31. [DOI:10.46624/ajptr.2019.v9.i3.027]
2. Singh S, Patil VM, Paliwal SK, Masand N. Nanotechnology-based drug delivery of topical antifungal agents. Pharm Nanotechnol. 2024 Sep;12(3):185-96. [DOI:10.2174/2211738511666230818125031] [PMID]
3. Ghods K, Akbari P, Ashkezari P, Ghayoomi S. Newest developments of nanotechnology in dentistry: a review of literature. J Dent Mater Tech. 2022 Mar;11:1-10.
4. Malik S, Waheed Y. Emerging applications of nanotechnology in dentistry. Dent J (Basel). 2023 Nov;11(11). [DOI:10.3390/dj11110266] [PMID] []
5. Roy Biswas G, Mazumder S, Majee S. Applications of nanorobots in medical techniques. Int J Pharm Sci & Res. 2020 Jul;11:2320-5148.
6. Jandt KD, Watts DC. Nanotechnology in dentistry: present and future perspectives on dental nanomaterials. Dent Mater. 2020 Nov;36(11):1365-78. [DOI:10.1016/j.dental.2020.08.006] [PMID] []
7. Kumar S S. Nanorobots a future device for diagnosis and treatment. J Pharm Pharm. 2018 Aug;5:44-9. [DOI:10.15436/2377-1313.18.1815]
8. Kong X, Gao P, Wang J, Fang Y, Hwang KC. Advances of medical nanorobots for future cancer treatments. J Hematol Oncol. 2023 Jul;16(1):74. [DOI:10.1186/s13045-023-01463-z] [PMID] []
9. Bavani T. The application in dentistry nano composite. J Bioelectron Nanotechnol. 2016 Jul;1(1):4. [DOI:10.13188/2475-224X.1000005]
10. Ahuja K, Panchbai A. Nano robotic dentistry-transforming fiction into reality. J Res Med Dent Sci. 2022 Jul;10:42-6.
11. Mahima A, Vaibhav G. Nanorobots in medicine: advancing healthcare through molecular engineering: a comprehensive review. IgMin Res. 2024 Nov;2(11):938-49. [DOI:10.61927/igmin271]
12. Subhash AS, Sanjay WM, Sanjay UV, Dadasaheb KS. Review on nanorobotics: the future of medicine. Asian J Pharm Res. 2024 Dec;14(4):387-91.
13. Huang D, Cai L, Li N, Zhao Y. Ultrasound‐trigged micro/nanorobots for biomedical applications. Smart Med. 2023 Apr;2(2):e20230003. [DOI:10.1002/SMMD.20230003] [PMID] []
14. Yuan M, Cao Z, Luo J, Chou X. Recent developments of acoustic energy harvesting: Review. Micromachines (Basel). 2019 Jan;10(1):48. [DOI:10.3390/mi10010048] [PMID] []
15. Krull A, Hirsch P, Rother C, Schiffrin A, Krull C. Artificial-intelligence-driven scanning probe microscopy. Commun Phys. 2020 Mar;3:54. [DOI:10.1038/s42005-020-0317-3]
16. Thomas P, Shenoy R, Jodalli P, Mohammed I, Bantwal J. Biosensors in the field of dentistry. J Clin Diagn Res. 2022 Jan;16(1). [DOI:10.7860/JCDR/2022/53025.15865]
17. Kishore C, Bhadra P. Targeting brain cancer cells by nanorobot, a promising nanovehicle: new challenges and future perspectives. CNS Neurol Disord Drug Targets.2021 Jun;20(6):531-9. [DOI:10.2174/1871527320666210526154801] [PMID]
18. Xu Y, Bian Q, Wang R, Gao J. Micro/nanorobots for precise drug delivery via targeted transport and triggered release: a review. Int J Pharm. 2022 Mar;616:121551. [DOI:10.1016/j.ijpharm.2022.121551] [PMID]
19. Li Y, Xu C, Lei C. The delivery and activation of growth factors using nanomaterials for bone repair. Pharmaceutics. 2023 Mar 22;15(3):1017. [DOI:10.3390/pharmaceutics15031017] [PMID] []
20. Wavhale RD, Dhobale KD, Rahane CS, Chate GP, Tawade BV, Patil YN, Gawade SS, Banerjee SS. Water-powered self-propelled magnetic nanobot for rapid and highly efficient capture of circulating tumor cells. Commun Chem. 2021 Nov;4(1):159. [DOI:10.1038/s42004-021-00598-9] [PMID] []
21. Wang Z, Wang C, Ji Y, Yang M, Li C, Li M, et al. Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting. Innovation (Camb). 2025 Jan;6(2):100777. [DOI:10.1016/j.xinn.2024.100777] [PMID] []
22. Wang Q, Chang R, Li X, Zhang Y, Fan X, Shi L, et al. Logic-Gated DNA intelligent nanorobots for cellular lysosome interference and enhanced therapeutics. Angew Chem Int Ed Engl. 2025 Apr;64(15):e202423004. [DOI:10.1002/anie.202423004] [PMID]
23. Oral CM, Pumera M. In vivo applications of micro/nanorobots. Nanoscale. 2023 Apr;15(19):8491-507. [DOI:10.1039/D3NR00502J] [PMID]
24. Abiodun-Solanke I, Ajayi D, Arigbede A. Nanotechnology and its application in dentistry. Ann Med Health Sci Res. 2014 Sep;4(Suppl 3):S171-7. [DOI:10.4103/2141-9248.141951] [PMID] []
25. Yin Z, Liu Y, Anniwaer A, You Y, Guo J, Tang Y, et al. Rational designs of biomaterials for combating oral biofilm infections. Adv Mater. 2025 Aug;37(31):e2305633. [DOI:10.1002/adma.202305633] [PMID]
26. Totu EE, Isildak I, Nechifor AC, Cristache CM, Enachescu M. New sensor based on membranes with magnetic nano-inclusions for early diagnosis in periodontal disease. Biosens Bioelectron. 2018 Apr 15;102:336-44. [DOI:10.1016/j.bios.2017.11.003] [PMID]
27. Han L, Chen M, Yan Z, Song Y, Zhou D, Pan L, et al. A novel MNPs@GO biosensor- integrated upconversion fluorescence cuvette for simultaneous detection of Salmonella typhimurium and Staphylococcus aureus. Microchem J. 2024 Jul;204:111149. [DOI:10.1016/j.microc.2024.111149]
28. Arqué X, Torres MDT, Patiño T, Boaro A, Sánchez S, de la Fuente-Nunez C. Autonomous treatment of bacterial infections in vivo using antimicrobial micro- and nanomotors. ACS Nano. 2022 May;16(5):7547-58. [DOI:10.1021/acsnano.1c11013] [PMID] []
29. Peng X, Oral CM, Urso M, Ussia M, Pumera M. Active microrobots for dual removal of biofilms via chemical and physical mechanisms. ACS Appl Mater Interfaces. 2025 Jan;17(2):3608-3619. [DOI:10.1021/acsami.4c18360] [PMID] []
30. Mayorga-Martinez CC, Zelenka J, Klima K, Kubanova M, Ruml T, Pumera M. Multimodal-driven magnetic microrobots with enhanced bactericidal activity for biofilm eradication and removal from titanium mesh. Adv Mater. 2023 Jun;35(23):e2300191. [DOI:10.1002/adma.202300191] [PMID]
31. Lertpimonchai A, Rattanasiri S, Arj-Ong Vallibhakara S, Attia J, Thakkinstian A. The association between oral hygiene and periodontitis: a systematic review and meta-analysis. Int Dent J. 2017 Dec;67(6):332-43. [DOI:10.1111/idj.12317] [PMID] []
32. Kelotte D, Melath A, Kaykool S, Chandran N. Nanotechnology and periodontics. J Periodontal Implant Sci. 2023 Aug;53(4):245-7. [DOI:10.5051/jpis.235304edi01] [PMID] []
33. Mani S, Sachdeva S, Mani A, Vora H, Gholap S, Sodhi J. Nano-robotics: the future of health and dental care. IP Int J Periodontol Implantol. 2021 Feb;6(1):6-10. [DOI:10.18231/j.ijpi.2021.002]
34. Dasgupta D, Peddi S, Saini DK, Ghosh A. Mobile nanobots for prevention of root canal treatment failure. Adv Healthc Mater. 2022 Jul;11(14):e2200232. [DOI:10.1002/adhm.202200232] [PMID] []
35. Babeer A, Bukhari S, Alrehaili R, Karabucak B, Koo H. Microrobotics in endodontics: a perspective. Int Endod J. 2024 Jul;57(7):861-71. [DOI:10.1111/iej.14082] [PMID] []
36. Wang YL, Liu ZJ. Unique features of nanomaterials and their combination support applications in orthodontics. Chin J Dent Res. 2023 Sep 21;26(3):143-52.
37. Al-Abboodi J, Fakrurrozi Mohamad A, Fazliah Mohd Noor SN, Ahmad Shafiai NA. Nanotechnology in orthodontics: revolutionizing interventions through tiny particles. J Nanostruct. 2024 Oct;14(4):1134-42.
38. Adel S, Zaher A, El Harouni N, Venugopal A, Premjani P, Vaid N. Robotic applications in orthodontics: changing the face of contemporary clinical care. Biomed Res Int. 2021 Jun;2021:9954615. [DOI:10.1155/2021/9954615] [PMID] []
39. He L, Zhang W, Liu J, Pan Y, Li S, Xie Y. Applications of nanotechnology in orthodontics: a comprehensive review of tooth movement, antibacterial properties, friction reduction, and corrosion resistance. Biomed Eng Online. 2024 Jul;23(1):72. [DOI:10.1186/s12938-024-01261-9] [PMID] []
40. Balhaddad AA, Kansara AA, Hidan D, Weir MD, Xu HHK, Melo MAS. Toward dental caries: exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials. Bioact Mater. 2018 Dec;4(1):43-55. [DOI:10.1016/j.bioactmat.2018.12.002] [PMID] []
41. Dipalma G, Inchingolo AD, Guglielmo M, Morolla R, Palumbo I, Riccaldo L, et al. Nanotechnology and its application in dentistry: a systematic review of recent advances and innovations. J Clin Med. 2024 Sep 5;13(17):5268. [DOI:10.3390/jcm13175268] [PMID] []
42. Marto CM, Baptista Paula A, Nunes T, Pimenta M, Abrantes AM, Pires AS, et al. Evaluation of the efficacy of dentin hypersensitivity treatments-a systematic review and follow-up analysis. J Oral Rehabil. 2019 Oct;46(10):952-90. [DOI:10.1111/joor.12842] [PMID]
43. Toledano-Osorio M, Osorio E, Aguilera FS, Luis Medina-Castillo A, Toledano M, Osorio R. Improved reactive nanoparticles to treat dentin hypersensitivity. Acta Biomater. 2018 May;72:371-80. [DOI:10.1016/j.actbio.2018.03.033] [PMID]
44. Li J, Esteban-Fernández de Ávila B, Gao W, Zhang L, Wang J. Micro/nanorobots for biomedicine: delivery, surgery, sensing, and detoxification. Sci Robot. 2017 Mar;2(4):eaam6431. [DOI:10.1126/scirobotics.aam6431] [PMID] []
45. Abaszadeh F, Ashoub MH, Khajouie G, Amiri M. Nanotechnology development in surgical applications: recent trends and developments. Eur J Med Res. 2023 Nov;28(1):537. [DOI:10.1186/s40001-023-01429-4] [PMID] []
46. Bordoloi P, Shahira S, Ramesh A, Thomas B. Nanorobotic wonders: a revolutionary era in periodontics. Indian J Multidiscip Dent. 2018 Jan;8(2):101.
47. Vyskočil J, Mayorga Martinez C, Jablonska E, Novotný F, Ruml T, Pumera M. Cancer cells microsurgery via asymmetric bent surface Au/Ag/Ni microrobotic scalpels through a transversal rotating magnetic field. ACS Nano. 2020 Jun;14(7). [DOI:10.1021/acsnano.0c01705] [PMID]
48. Ussia M, Urso M, Kment S, Fialova T, Klima K, Dolezelikova K, et al. Light-propelled nanorobots for facial titanium implants biofilms removal. Small. 2022 Jun;18(22):e2200708. [DOI:10.1002/smll.202200708] [PMID]
49. Chen G, Zhu F, Gan ASJ, Mohan B, Dey KK, Xu K, et al. Towards the next generation nanorobots. Next Nanotechnol. 2023 Jun;2:100019. [DOI:10.1016/j.nxnano.2023.100019]
50. Ghods K, Azizi A, Jafari A, Ghods K. Application of artificial intelligence in clinical dentistry, a comprehensive review of literature. J Dent (Shiraz). 2023 Dec 1;24(4):356-71.
51. Singh AV, Chandrasekar V, Janapareddy P, Mathews DE, Laux P, Luch A, et al. Emerging application of nanorobotics and artificial intelligence to cross the BBB: advances in design, controlled maneuvering, and targeting of the barriers. ACS Chem Neurosci. 2021 Jun;12(11):1835-53. [DOI:10.1021/acschemneuro.1c00087] [PMID]
52. Biswas M. AI-powered nanorobots: a mini review on innovations in healthcare. J Artif Intell. 2024 Aug;1(2):1-4.
53. Dong H, Lin J, Tao Y, Jia Y, Sun L, Li W, et al. AI-enhanced biomedical micro/nanorobots in microfluidics. Lab Chip. 2024 Jan;24:1419-40. [DOI:10.1039/D3LC00909B] [PMID]
54. Balusamy B, Dhanaraj RK, Seetharaman T, Sharma V, Shankar A, Viriyasitavat W. Design control and management of intelligent and autonomous nanorobots with artificial intelligence for Prevention and monitoring of blood related diseases. Eng Appl Artif Intell. 2024;131:107798. [DOI:10.1016/j.engappai.2023.107798]
55. Peng X, Oral CM, Urso M, Ussia M, Pumera M. Active microrobots for dual removal of biofilms via chemical and physical mechanisms. ACS Appl Mater Interfaces. 2025 Jan;17(2):3608-3619. [DOI:10.1021/acsami.4c18360] [PMID] []
56. Han H, Ma X, Deng W, Zhang J, Tang S, Pak OS, et al. Imaging-guided bioresorbable acoustic hydrogel microrobots. Sci Robot. 2024 Dec 11;9(97):eadp3593. [DOI:10.1126/scirobotics.adp3593] [PMID]
57. Kralj S, Da Silva C, Nemec S, Caf M, Fourquaux I, Rols MP, et al. Dynamically assembling magnetic nanochains as new generation of swarm-type magneto-mechanical nanorobots affecting biofilm integrity. Adv Healthc Mater. 2025 Mar;14(6):e2403736. [DOI:10.1002/adhm.202403736] [PMID]
58. Ma X, Tian Y, Yang R, Wang H, Allahou LW, Chang J, et al. Nanotechnology in healthcare, and its safety and environmental risks. J Nanobiotechnology. 2024 Nov;22(1):715. [DOI:10.1186/s12951-024-02901-x] [PMID] []
59. Giri G, Maddahi Y, Zareinia K. A brief review on challenges in design and development of nanorobots for medical applications. Appl Sci. 2021 Nov;11(21):10385. [DOI:10.3390/app112110385]
60. Weerarathna IN, Kumar P, Dzoagbe HY, Kiwanuka L. Advancements in micro/nanorobots in medicine: design, actuation, and transformative application. ACS Omega. 2025 Feb;10(6):5214-5250. [DOI:10.1021/acsomega.4c09806] [PMID] []

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