دوره 9، شماره 3 - ( 6-1403 )
جلد 9 شماره 3 صفحات 158-151 |
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Ethics code: IR.SSU.REC.1399.314
Clinical trials code: IRCT20210306050606N1
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Barzegar M, Ghadirian H, Roustaeizade Shooroki Z, Yektaie M A, Pouyafard A. Comparative Efficacy of Triadent and Ora-Aid Mucoadhesive Patch for Treatment of Minor Aphthous Ulcers: A Clinical Trial. J Res Dent Maxillofac Sci 2024; 9 (3) :151-158
URL: http://jrdms.dentaliau.ac.ir/article-1-572-fa.html
URL: http://jrdms.dentaliau.ac.ir/article-1-572-fa.html
Comparative Efficacy of Triadent and Ora-Aid Mucoadhesive Patch for Treatment of Minor Aphthous Ulcers: A Clinical Trial. . 1403; 9 (3) :151-158
چکیده: (1304 مشاهده)
Background and Aim: This study aimed to compare the effects of Triadent (triamcinolone mucoadhesive paste) and Ora-Aid mucoadhesive patch on the severity of pain, burning sensation, and size of minor aphthous ulcers.
Materials and Methods: This double-blind clinical trial was conducted on 40 patients with minor aphthous ulcers. The patients were randomly assigned to two groups (n=20) to use Triadent paste or Ora-Aid mucoadhesive patch (3 times/day). The severity of pain and burning sensation of patients was quantified by a visual analog scale (VAS). Size of lesions was also measured before, and at 3, 5, and 7 days after the treatment by using a graded paper placed next to the lesions. Data were analyzed by the t-test and the Mann-Whitney test (alpha=0.05).
Results: The mean reduction in lesion diameter at 3 days (compared with baseline) was significantly greater in the Ora-Aid than the Triadent group (P=0.000). However, the mean reduction in lesion diameter at 5 and 7 days was significantly greater in the Triadent group (P=0.000). The mean reduction in the severity of pain and burning sensation was significantly greater in the Ora-Aid group than the Triadent group at 3, 5, and 7 days (P=0.000).
Conclusion: Both Triadent and Ora-Aid significantly decreased pain, burning sensation, and size of minor aphthous lesions. However, Triadent was significantly more effective for reduction of size of lesions while Ora-Aid was significantly more effective for reduction of pain and burning sensation.
Materials and Methods: This double-blind clinical trial was conducted on 40 patients with minor aphthous ulcers. The patients were randomly assigned to two groups (n=20) to use Triadent paste or Ora-Aid mucoadhesive patch (3 times/day). The severity of pain and burning sensation of patients was quantified by a visual analog scale (VAS). Size of lesions was also measured before, and at 3, 5, and 7 days after the treatment by using a graded paper placed next to the lesions. Data were analyzed by the t-test and the Mann-Whitney test (alpha=0.05).
Results: The mean reduction in lesion diameter at 3 days (compared with baseline) was significantly greater in the Ora-Aid than the Triadent group (P=0.000). However, the mean reduction in lesion diameter at 5 and 7 days was significantly greater in the Triadent group (P=0.000). The mean reduction in the severity of pain and burning sensation was significantly greater in the Ora-Aid group than the Triadent group at 3, 5, and 7 days (P=0.000).
Conclusion: Both Triadent and Ora-Aid significantly decreased pain, burning sensation, and size of minor aphthous lesions. However, Triadent was significantly more effective for reduction of size of lesions while Ora-Aid was significantly more effective for reduction of pain and burning sensation.
موضوع مقاله:
Oral medicine
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