Volume 9, Issue 2 (6-2024)
J Res Dent Maxillofac Sci 2024, 9(2): 94-99 |
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Mirmohammadi K, Fattahi S, Tavakoli F, Tashakor A. Prevalence of Dysplasia in Oral Lichen Planus Patients. J Res Dent Maxillofac Sci 2024; 9 (2) :94-99
URL: http://jrdms.dentaliau.ac.ir/article-1-531-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-531-en.html
1- Department of Orthodontics, Faculty of Dentistry, Tehran Azad University of Medical Sciences, Tehran, Iran. , Mirmohammadi_kamal@yahoo.com
2- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
3- Oral and Maxillofacial Medicine Department, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Orthodontics, Faculty of Dentistry, Tehran Azad University of Medical Sciences, Tehran, Iran.
2- Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
3- Oral and Maxillofacial Medicine Department, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Orthodontics, Faculty of Dentistry, Tehran Azad University of Medical Sciences, Tehran, Iran.
Abstract: (1009 Views)
Background and Aim: Lichen planus (LP) is a chronic inflammatory mucocutaneous disease usually diagnosed based on clinical and histopathological findings. Prognostic evaluation of malignant transformation in LP is clinically and histologically complex. Due to the inconsistent results of previous studies regarding the prevalence of dysplastic changes in LP, this study aimed to evaluate the prevalence of dysplasia in oral lichen planus (OLP) patients.
Materials and Methods: This cross-sectional study was conducted on biopsy samples of OLP patients referred to Tabriz Dental Faculty from 2012 to 2020. The diagnosis of OLP was based on the World Health Organization criteria, which was confirmed by reassessment of the microscopic slides by a pathologist. The clinical subtype of OLP samples was specified based on the information present in patient files. Data were analyzed by the Chi-square test using SPSS 17 (alpha=0.05).
Results: The buccal mucosa was the most commonly involved area (27 out of 36 cases). The tongue ranked next (10 out of 36 cases). The most common clinical subtype was reticular form with 23 cases (63.9%). In 8 cases (21.9%), epithelial dysplasia was observed; of which, 7 cases were grade I and 1 was grade II. Among the observed dysplastic features, nuclear hyperchromatosis and enlarged nucleus had the highest incidence (11.1%).
Conclusion: The percentage of dysplasia in OLP specimens was not high in the study population. However, considering the risk of transformation to squamous cell carcinoma (SCC), accurate diagnosis of SCC based on history, and clinical and histopathological findings is critical. In case of histopathological detection of dysplasia, long-term follow-up of patients is necessary.
Materials and Methods: This cross-sectional study was conducted on biopsy samples of OLP patients referred to Tabriz Dental Faculty from 2012 to 2020. The diagnosis of OLP was based on the World Health Organization criteria, which was confirmed by reassessment of the microscopic slides by a pathologist. The clinical subtype of OLP samples was specified based on the information present in patient files. Data were analyzed by the Chi-square test using SPSS 17 (alpha=0.05).
Results: The buccal mucosa was the most commonly involved area (27 out of 36 cases). The tongue ranked next (10 out of 36 cases). The most common clinical subtype was reticular form with 23 cases (63.9%). In 8 cases (21.9%), epithelial dysplasia was observed; of which, 7 cases were grade I and 1 was grade II. Among the observed dysplastic features, nuclear hyperchromatosis and enlarged nucleus had the highest incidence (11.1%).
Conclusion: The percentage of dysplasia in OLP specimens was not high in the study population. However, considering the risk of transformation to squamous cell carcinoma (SCC), accurate diagnosis of SCC based on history, and clinical and histopathological findings is critical. In case of histopathological detection of dysplasia, long-term follow-up of patients is necessary.
Type of Study: Original article |
Subject:
Oral pathology
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