Volume 9, Issue 2 (6-2024)
J Res Dent Maxillofac Sci 2024, 9(2): 71-79 |
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Ethics code: IR.IAU.DENTAL.REC.1397.037
Clinical trials code: IRCT20120311009260N3
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Karimi M R, Sadatmansouri S, Anoush G, Montazeri M, Taheri N. Effect of Cyanoacrylate Adhesive on Palatal Wound Healing Following Free Gingival Grafting: A Clinical Trial. J Res Dent Maxillofac Sci 2024; 9 (2) :71-79
URL: http://jrdms.dentaliau.ac.ir/article-1-485-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-485-en.html
Mohammad Reza Karimi1 
, Saeed Sadatmansouri1 
, Ghazal Anoush2 , Mostafa Montazeri * 3, Nastaran Taheri2
, Saeed Sadatmansouri1 , Ghazal Anoush2 , Mostafa Montazeri * 3, Nastaran Taheri2
1- Department of Periodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
2- Private Dental Practice, Tehran, Iran.
3- Department of Periodontics, School of Dentistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran. ,mosimont@gmail.com
2- Private Dental Practice, Tehran, Iran.
3- Department of Periodontics, School of Dentistry, Shiraz Branch, Islamic Azad University, Shiraz, Iran. ,
Abstract: (558 Views)
Background and Aim: This study investigated the effect of applying cyanoacrylate adhesive on clinical indices involved in the healing process of the palatal wound following free gingival graft (FGG) harvesting.
Materials and Methods: In this randomized controlled clinical trial, 15 patients who required bilateral FGG harvesting were randomly assigned to two groups. In the suture group, the wound was closed by Vicryl 4-0 sutures; whereas in the control group, the wound closure and hemostasis were attained by applying a concentrated mixture of n-butyl and 2-octyl cyanoacrylate. The primary outcomes included pain according to a visual analog scale (VAS), discomfort, healing rate, early and late bleeding, ease of feeding, wound epithelization rate, and sensory disturbances within one week and three months following the surgery. Statistical analysis was performed with the Chi-square and Mann-Whitney U tests (alpha=0.05).
Results: Cyanoacrylate application on the wound was significantly faster than suturing (2.12±1.23 minutes vs. 8.42±2.24 minutes, P<0.0001). The mean postoperative pain score (P=0.015), patient discomfort (P=0.017), and healing rate (P=0.024) were significantly more favorable in the cyanoacrylate group compared to the control group during the first week after surgery. Rate of wound epithelialization showed no significant difference between the two groups (P>0.05).
Conclusion: Application of cyanoacrylate adhesive to enhance the healing of palatal donor site wound decreased pain and discomfort and enhanced healing during the first postoperative week. In general, cyanoacrylate application is comparable to suturing in palatal wound healing and may be used for faster (by 6 minutes) closure of FGG wounds.
Materials and Methods: In this randomized controlled clinical trial, 15 patients who required bilateral FGG harvesting were randomly assigned to two groups. In the suture group, the wound was closed by Vicryl 4-0 sutures; whereas in the control group, the wound closure and hemostasis were attained by applying a concentrated mixture of n-butyl and 2-octyl cyanoacrylate. The primary outcomes included pain according to a visual analog scale (VAS), discomfort, healing rate, early and late bleeding, ease of feeding, wound epithelization rate, and sensory disturbances within one week and three months following the surgery. Statistical analysis was performed with the Chi-square and Mann-Whitney U tests (alpha=0.05).
Results: Cyanoacrylate application on the wound was significantly faster than suturing (2.12±1.23 minutes vs. 8.42±2.24 minutes, P<0.0001). The mean postoperative pain score (P=0.015), patient discomfort (P=0.017), and healing rate (P=0.024) were significantly more favorable in the cyanoacrylate group compared to the control group during the first week after surgery. Rate of wound epithelialization showed no significant difference between the two groups (P>0.05).
Conclusion: Application of cyanoacrylate adhesive to enhance the healing of palatal donor site wound decreased pain and discomfort and enhanced healing during the first postoperative week. In general, cyanoacrylate application is comparable to suturing in palatal wound healing and may be used for faster (by 6 minutes) closure of FGG wounds.
Keywords: Tissue adhesives, Wound healing, Cyanoacrylates, Transplantation, Gingiva, Pain, Postoperative
Type of Study: Randomized Clinical Trial |
Subject:
Periodontology
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