Volume 8, Issue 3 (8-2023)
J Res Dent Maxillofac Sci 2023, 8(3): 226-235 |
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Tabatabaeian M, Esfahanian V. Effect of Acemannan/Aloe Vera on Bone Regeneration Specially in the Oral and Maxillofacial Region: A Literature Review. J Res Dent Maxillofac Sci 2023; 8 (3) :226-235
URL: http://jrdms.dentaliau.ac.ir/article-1-479-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-479-en.html
1- School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2- Department of Periodontology, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran ,vahid.esfahanian@gmail.com
2- Department of Periodontology, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran ,
Abstract: (801 Views)
| Background and Aim: With the advances in technology, the use of natural materials has broadened. Acemannan is the main polysaccharide in aloe vera plant. It is a natural and biocompatible polymer with low toxicity. The acemannan monomers include mannose, glucose and galactose. Due to its biological properties, acemannan could be useful in bone regeneration. The aim of this study was to investigate the effect of acemannan/aloe vera on bone regeneration and extraction socket healing. Materials and Methods: In this review article, an electronic search was conducted in PubMed and Scopus from 1996 to June 2022. Relevant data based on clinical indications were extracted. Twenty original articles, including 4 in vitro studies, 8 animal, and 8 human studies were reviewed. The inclusion criterion was articles that directly and originally evaluated the correlation of bone regeneration and acemannan/aloe vera. Results: Over 30 studies were found in this field by database searching. According to the results, the proposed items could be categorized into 3 major groups of animals, human, and in vitro studies. Animal studies were divided into two groups of bone defect regeneration and extraction socket healing. Also, human studies were divided into two groups of bone defect regeneration and sinus floor elevation/guided bone regeneration surgeries. All studies reported positive effect of Acemannan/aloe vera on bone healing and regeneration. Conclusion: Acemannan/aloe vera may be considered as a bioactive molecule due to induction and acceleration of bone formation. |
Type of Study: Review article |
Subject:
Periodontology
References
1. Azari Matin A, Fattah K, Saeidpour Masouleh S, Tavakoli R, Houshmandkia SA, Moliani A, Moghimimonfared R, Pakzad S, Dalir Abdolahinia E. Synthetic electrospun nanofibers as a sup-portive matrix in osteogenic differentiation of induced pluripo-tent stem cells. J Biomater Sci Polym Ed. 2022 Aug; 33(11):1469-93. [DOI:10.1080/09205063.2022.2056941] [PMID]
2. Moghadam E, Yazdanian M, Alam M, Tebyaniyan H, Tafazoli A, Tahmasebi E, et al. Current Natural Bioactive Materi-als in Bone and Tooth Regeneration in dentistry: A Comprehen-sive Overview. J Mater Res Technol. 2021 Jul 1; 13:2078-114.
3. Putra Gofur NR, Putri Gofur AR, Kemal AA, Soesilaningtyas RN, Kahdina M. Combination of PDLSCs and Nanocomposite-fibrous Scaffold as Alveolar Ridge Preservation in Geriatric Patients before The Prostheses Inser-tion. International Surgery Case Reports. 2021 Apr 19; 2(3).
4. Tran TT, Hamid ZA, Cheong KY. A review of mechanical prop-erties of scaffold in tissue engineering: aloe vera composites. Journal of Physics Conference Series. 2018 Aug; 1082. [DOI:10.1088/1742-6596/1082/1/012080]
5. Costa CR, Amorim BR, de Magalhães P, De Luca Canto G, Acevedo AC, Guerra EN. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytother Res. 2016 Apr;30(4): 519-31. [DOI:10.1002/ptr.5568]
6. Jansisyanont P, Tiyapongprapan S, Chuenchompoonut V, Sangvanich P, Thunyakitpisal P. The effect of acemannan sponges in post-extraction socket healing: A randomized trial. J Oral Maxillofac Surg Med Pathol. 2016;28(2):105-10. [DOI:10.1016/j.ajoms.2015.07.006]
7. Bose S, Sarkar N, Banerjee D. Natural medicine delivery from biomedical devices to treat bone disorders: A review. Acta Bio-mater. 2021 May;126:63-91. [DOI:10.1016/j.actbio.2021.02.034] [PMID] [PMCID]
8. Kim DM, Lee HK, Kwon YS, Choi YM. Enhanced bone regeneration by Aloe vera gel conjugated barnacle cement pro-tein composite hyaluronic acid hydrogel based hydroxyapatite derived from cuttlefish bone. Medical & Clinical Research. 2022;7(3):18-26. [DOI:10.33140/MCR.07.03.02]
9. Godoy DJD, Chokboribal J, Pauwels R, Banlunara W, Sangvanich P, Jaroenporn S, Thunyakitpisal P. Acemannan in-creased bone surface, bone volume, and bone density in a calvar-ial defect model in skeletally-mature rats. J Dent Sci. 2018 Dec;13(4):334-341. [DOI:10.1016/j.jds.2018.06.004] [PMID] [PMCID]
10. Ege B, Ege M. The Therapeutic Applications of Phytopharmaceuticals in Dentistry. Phytopharmaceuticals. 2021 Jun 3:191-222. [DOI:10.1002/9781119682059.ch10]
11. Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A. Acemannan, an extracted poly-saccharide from Aloe vera: A literature review. Nat Prod Com-mun. 2014 Aug;9(8):1217-21. [DOI:10.1177/1934578X1400900836]
12. Kumar R, Singh AK, Gupta A, Bishayee A, Pandey AK. Thera-peutic potential of Aloe vera-A miracle gift of nature. Phytomed-icine. 2019 Jul;60:152996. [DOI:10.1016/j.phymed.2019.152996] [PMID]
13. Svitina H, Hamman JH, Gouws C. Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review). Exp Ther Med. 2021 Aug;22(2):852. [DOI:10.3892/etm.2021.10284] [PMID] [PMCID]
14. Darzi S, Paul K, Leitan S, Werkmeister JA, Mukherjee S. Im-munobiology and Application of Aloe Vera-Based Scaffolds in Tissue Engineering. Int J Mol Sci. 2021 Feb 8;22 (4):1708. [DOI:10.3390/ijms22041708] [PMCID]
15. Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W, Thunyakitpisal P. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci. 2009 Apr; 109(4):525-31. [DOI:10.1254/jphs.08204FP] [PMID]
16. Jittapiromsak N, Jettanacheawchankit S, Lardungdee P, Sangvanich P, Thunyakitpisal P. (2007). Effect of acemannan on BMP-2 expression in primary pulpal fibroblasts and periodontal fibroblasts, in vitro study. Journal of oral tissue engineering. 2007;4(3):149-54.
17. Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P, Thunyakitpisal P. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Eng Part A. 2010 Jun;16(6):1997-2006. [DOI:10.1089/ten.tea.2009.0593] [PMID]
18. Chantarawaratit P, Sangvanich P, Banlunara W, Soontornvipart K, Thunyakitpisal P. Acemannan sponges stimu-late alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. J Periodontal Res. 2014 Apr;49(2):164-78. [DOI:10.1111/jre.12090] [PMID]
19. Rahman S, Carter P, Bhattarai N. Aloe Vera for Tissue Engi-neering Applications. J Funct Biomater. 2017 Feb 14;8 (1):6. [DOI:10.3390/jfb8010006] [PMCID]
20. Deesricharoenkiat N, Jansisyanont P, Chuenchompoonut V, Mattheos N, Thunyakitpisal P. The effect of acemannan in im-plant placement with simultaneous guided bone regeneration in the aesthetic zone: a randomized controlled trial. Int J Oral Maxillofac Surg. 2022 Apr;51(4):535-44. [DOI:10.1016/j.ijom.2021.07.017] [PMID]
21. Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996 Nov; 35 (2):119-28. [DOI:10.1016/S0162-3109(96)00135-X]
22. Tahmasebi A, Shapouri Moghadam A, Enderami SE, Islami M, Kaabi M, Saburi E, Daei Farshchi A, Soleimanifar F, Mansouri V. Aloe Vera-Derived Gel-Blended PHBV Nanofibrous Scaffold for Bone Tissue Engineering. ASAIO J. 2020 Aug;66(8):966-73. [DOI:10.1097/MAT.0000000000001094] [PMID]
23. Rasoulian B, Almasi A, Hoveizi E, Bagher Z, Hayat P, Joghataei MT, Rezayat SM, Tavakol S. Strong binding active constituents of phytochemical to BMPR1A promote bone regeneration: In vitro, in silico docking, and in vivo studies. J Cell Physiol. 2019 Aug;234(8):14246-258. [DOI:10.1002/jcp.28121] [PMID]
24. Al-Hijazi AY, Al-Mahammadawy AK, Altememe EI. Expression of BMP7 in bone tissue treated with Aloe vera. In-ternational Research Journal of Natural Sciences. 2015 June;3(2):39-48.
25. Soares IMV, Fernandes GVO, Larissa Cordeiro C, Leite YKPC, Bezerra DO, Carvalho MAM, Carvalho CMRS. The influence of Aloe vera with mesenchymal stem cells from dental pulp on bone regeneration: characterization and treatment of non-critical defects of the tibia in rats. J Appl Oral Sci. 2019;27:e20180103. [DOI:10.1590/1678-7757-2018-0103] [PMID] [PMCID]
26. Banerjee D, Bose S. Effects of Aloe Vera Gel Extract in Doped Hydroxyapatite-Coated Titanium Implants on in Vivo and in Vitro Biological Properties. ACS Appl Bio Mater. 2019 Aug 19;2(8):3194-202. [DOI:10.1021/acsabm.9b00077] [PMID]
27. Pachimalla PR, Mishra SK, Chowdhary R. Evaluation of hy-drophilic gel made from Acemannan and Moringa oleifera in enhancing osseointegration of dental implants. A preliminary study in rabbits. J Oral Biol Craniofac Res. 2020 Apr-Jun;10(2):13-9. [DOI:10.1016/j.jobcr.2020.01.005] [PMID] [PMCID]
28. Elsheshtawy A, Eltokhey H, Abd Elhamid A, Albastawisy Hassa G. Topical Effect of Aloe Vera Gel versus Silver Nanoparticles on Socket Healing in Methylprednisolone Treated Albino Rats. Egyptian Journal of Histology. 2021;44 (2):436-49.
29. Boonyagul S, Banlunara W, Sangvanich P, Thunyakitpisal P. Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone for-mation in a tooth extraction model. Odontology. 2014 Jul; 102(2):310-7. [DOI:10.1007/s10266-012-0101-2] [PMID]
30. Trinh HA, Dam VV, Le B, Pittayapat P, Thunyakitpisal P. Indirect Sinus Augmentation With and Without the Addition of a Biomaterial: A Randomized Controlled Clinical Trial. Implant Dent. 2019 Dec;28(6):571-7. [DOI:10.1097/ID.0000000000000941] [PMID]
31. Trinh HA, Dam VV, Banlunara W, Sangvanich P, Thunyakitpisal P. Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation. Case Rep Dent. 2020 Feb 13;2020:1675653. [DOI:10.1155/2020/1675653] [PMID] [PMCID]
32. Ipshita S, Kurian IG, Dileep P, Kumar S, Singh P, Pradeep AR. One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial. J Investig Clin Dent. 2018 Aug;9(3):e12334. [DOI:10.1111/jicd.12334] [PMID]
33. Kurian IG, Dileep P, Ipshita S, Pradeep AR. Comparative eval-uation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodonti-tis patients: A randomized, controlled clinical trial. J Investig Clin Dent. 2018 Aug;9(3): e12324. [DOI:10.1111/jicd.12324] [PMID]
34. Le Van C, Thi Thu HP, Sangvanich P, Chuenchompoonut V, Thunyakitpisal P. Acemannan induces rapid early osseous de-fect healing after apical surgery: A 12-month follow-up of a ran-domized controlled trial. J Dent Sci. 2020 Sep;15 (3): 302-9. [DOI:10.1016/j.jds.2019.09.012] [PMID] [PMCID]
35. Poor MR, Hall JE, Poor AS. Reduction in the incidence of al-veolar osteitis in patients treated with the SaliCept patch, con-taining Acemannan hydrogel. J Oral Maxillofac Surg. 2002 Apr;60(4):374-9.. [DOI:10.1053/joms.2002.31222] [PMID]
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