Volume 8, Issue 3 (8-2023)                   J Res Dent Maxillofac Sci 2023, 8(3): 221-225 | Back to browse issues page

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Masannan Mozaffari P, Saeedi N, Mohtasham M, Khosravi F, Farjami F. Giant Cell Fibroma of the Oral Cavity: Case Series and Literature Review. J Res Dent Maxillofac Sci 2023; 8 (3) :221-225
URL: http://jrdms.dentaliau.ac.ir/article-1-439-en.html
1- Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2- Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran , mahdi__sa1993@yahoo.com
3- Department of Oral and Maxillofacial Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
4- Department of Cosmetic Medicine and Restorative Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
5- Department of Orofacial medicine, Borås Hospital, Sweden
Abstract:   (219 Views)
Background and Aim: Oral giant cell fibroma (GCF) is a benign fibrous tumor that is histologically characterized by large, stellate, and mono- or multinucleated giant cells. GCF is an asymptomatic, sessile, or pedunculated exophytic lesion, usually smaller than 1 cm, with a smooth or papillary surface and the same color as the oral mucosa. The role of trauma in development of GCF has been contradictory. Knowledge about the characteristics of this lesion can help in diagnosis, treatment and follow-up of patients.  
Case Presentation: This article describes five cases of GCF in Iranian patients, two of which were found in an uncommon location (buccal mucosa). Two were larger than usual (> 1 cm) and one had clinical manifestations resembling pyogenic granuloma. Patients were selected from two oral medicine centers.
Conclusion: To distinguish GCF from other types of irritation fibroma, size, location, and presence or absence of stimulating factors should not preclude diagnosis. The diagnosis is confirmed by detection of giant cells in histological examination.
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Type of Study: Review article | Subject: Oral medicine

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