Volume 7, Issue 3 (Journal of Research in Dental & Maxillofacial Sciences Summer 2022)                   J Res Dent Maxillofac Sci 2022, 7(3): 133-141 | Back to browse issues page


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Baharvand M, Hakemi-Vala M, Mehdipour M, Dehghani L, Jalali E, Anbari F. Minimum Inhibitory Concentration of Peganum Harmala Extract Against Candida Species. J Res Dent Maxillofac Sci. 2022; 7 (3) :133-141
URL: http://jrdms.dentaliau.ac.ir/article-1-348-en.html
1- Department of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Microbiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Private Dental Practice, Oral & Maxillofacial Radiology private practice, Miami, Florida, USA
5- Department of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (85 Views)
Background and Aim: There are some rich sources of antifungals in medicinal herbs. They have general acceptance due to their low cost and insignificant side effects. The efficacy of Peganum harmala (P. harmala) extract against Candida species was investigated in this study.   
Materials and Methods: In this in vitro study, we used the maceration technique to obtain P. harmala aqueous and alcoholic extracts, and assess their antifungal activity against different species of Candida albicans (C. albicans), Candida glabrata (C. glabrata) and Candida krusei (C. krusei). We used the microdilution method to calculate the minimum inhibitory concentration (MIC). The tests were repeated in triplicate for higher accuracy.
Results: The aqueous and alcoholic P. harmala extracts showed antifungal activity against C. albicans in 100 mg/mL concentration. The antifungal efficacy of P. harmala alcoholic extract against C.
glabrata (MIC: 100 mg/mL) was higher than the aqueous extract (MIC:200 mg/mL). The antifungal efficacy of P. harmala alcoholic extract against C. krusei (MIC: 1.56 mg/mL) was higher than the aqueous extract (MIC: 12.5 mg/mL
).

Conclusion: The aqueous and alcoholic extracts of P. harmala were effective against all species of Candida particularly Candida krusei. The alcoholic extract of P. harmala was more effective than its aqueous extract against C. glabrata and C. krusei.
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Type of Study: Original article | Subject: Oral medicine

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