Volume 5, Issue 3 (8-2020)
J Res Dent Maxillofac Sci 2020, 5(3): 1-6 |
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Shirzaiy M, Neshat F. Effect of Areca Nut on Oral Health: A Review. J Res Dent Maxillofac Sci 2020; 5 (3) :1-6
URL: http://jrdms.dentaliau.ac.ir/article-1-276-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-276-en.html
1- Associated professor, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. , shirzaiy@gmail.com
2- Assistant professor, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences
2- Assistant professor, Oral and Dental Disease Research Center, Zahedan University of Medical Sciences
Abstract: (4303 Views)
Background and Aim: Oral health can be influenced by habitual areca nut chewing. The consumption of products containing areca nut, such as paan, gutkha, supari, etc., is common in Asian countries, such as India, Bangladesh, and Pakistan. In Iran, areca nut product consumption is common in the southeast of Iran, especially in Chabahar, Iranshahr, and Nikshahr cities, which are in proximity to the Pakistan border. These products are easily accessible in these areas and are widely used due to a lack of awareness about their disadvantages. Areca nut contains tannins and alkaloids, such as arecaidine, guvacine, arecoline, and guvacoline. Arecaidine can stimulate the synthesis of collagen by stimulation and proliferation of fibroblasts. This review article aims to evaluate the effects of areca nut on oral health.
Materials and Methods: Research was performed in the PubMed, ScienceDirect, Web of Science, Google Scholar, and Scopus databases, and 35 articles were selected in total.
Results: By reviewing the studies, it was found that areca nut products cause periodontal disease as well as oral lesions, which can become malignant with continuing use.
Conclusion: Areca nut product chewing has deleterious effects on oral and dental health. Tooth fracture, periodontal disease, leukoplakia, lichenoid lesions, oral submucous fibrosis (OSF), and oral cancer can be correlated with areca nut use. Therefore, public health proceeding to discontinue areca nut consumption is advised to control premalignant and malignant lesions, such as OSF and oral cancer.
Materials and Methods: Research was performed in the PubMed, ScienceDirect, Web of Science, Google Scholar, and Scopus databases, and 35 articles were selected in total.
Results: By reviewing the studies, it was found that areca nut products cause periodontal disease as well as oral lesions, which can become malignant with continuing use.
Conclusion: Areca nut product chewing has deleterious effects on oral and dental health. Tooth fracture, periodontal disease, leukoplakia, lichenoid lesions, oral submucous fibrosis (OSF), and oral cancer can be correlated with areca nut use. Therefore, public health proceeding to discontinue areca nut consumption is advised to control premalignant and malignant lesions, such as OSF and oral cancer.
Type of Study: Review article |
Subject:
Oral medicine
References
1. Anand R, Dhingra C, Prasad S, Menon I. Betel nut chewing and its deleterious effects on oral cavity. J Cancer Res Ther. 2014 Jul-Sep;10(3):499-505.
2. Auluck A, Hislop G, Poh C, Zhang L, Rosin MP. Areca nut and betel quid chewing among South Asian immigrants to Western countries and its implications for oral cancer screening. Rural Remote Health. 2009 Apr-Jun;9(2):1118.
3. Aziz SR. Coming to America: betel nut and oral submucous fibrosis. J Am Dent Assoc. 2010 Apr;141(4):423-8.
4. Pankaj C. Areca nut or Betel Nut Control is Mandatory if India wants to reduce the burden of Cancer especially Cancer of the Oral Cavity. Int J Head Neck Surg. 2010;1:17-20. [DOI:10.5005/jp-journals-10001-1003]
5. Verma S. Areca nut (betel nut) chewing: a popular Indian cultural practice and its mucosal implications. Int J Dermatol. 2011 Feb;50(2):229-32. [DOI:10.1111/j.1365-4632.2010.04710.x] [PMID]
6. Passi D, Bhanot P, Kacker D, Chahal D, Atri M, Panwar Y. Oral submucous fibrosis: Newer proposed classification with critical updates in pathogenesis and management strategies. Natl J Maxillofac Surg. 2017 Jul-Dec;8(2):89-94. [DOI:10.4103/njms.NJMS_32_17] [PMID] [PMCID]
7. Rajendran R, Rani V, Shaikh S. Pentoxifylline therapy: a new adjunct in the treatment of oral submucous fibrosis. Indian J Dent Res. 2006 Oct-Dec;17(4):190-8. [DOI:10.4103/0970-9290.29865] [PMID]
8. Dos M, Manjunath C, Srivastava A, Malavika J, Ameena MVM. Epidemiology of Oral Submucous Fibrosis: A Review. Int J Oral Health Med Res. 2017;3(6):126-9.
9. Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Abdollahi M. Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer. Epidemiol Health. 2017 Mar 9;39:e2017009. [DOI:10.4178/epih.e2017009] [PMID] [PMCID]
10. Hebbar PB, Sheshaprasad R, Gurudath S, Pai A, Sujatha D. Oral submucous fibrosis in India: Are we progressing?? Indian J Cancer. 2014 Jul-Sept;51(3):222-6. [DOI:10.4103/0019-509X.146724] [PMID]
11. Gupta PC, Sinor PN, Bhonsle RB, Pawar VS, Mehta HC. Oral submucous fibrosis in India: a new epidemic? Natl Med J India. 1998 May-Jun;11(3):113-6.
12. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines. Lyon (FR): International Agency for Research on Cancer; 2004. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 85.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK316567/
13. Parmar G, Sangwan P, Vashi P, Kulkarni P, Kumar S. Effect of chewing a mixture of areca nut and tobacco on periodontal tissues and oral hygiene status. J Oral Sci. 2008 Mar;50(1):57-62. [DOI:10.2334/josnusd.50.57] [PMID]
14. Shirzaii M, Momeni Z. Evaluation of oral submucosal fibrosis and related factors in areca nut users. Zahedan J Res Med Sci (ZJRMS). 2013;15(1):38-42.
15. Shirzaii M, Sarani M. Supari Consumption is a Common Oral Habit Among Women in Chabahar City. Int J High Risk Behav Addict. 2012;1(1):44-5. [DOI:10.5812/ijhrba.4177]
16. World Health Organization. Regional Office for the Western Pacific. Review of areca (betel) nut and tobacco use in the Pacific : a technical report. [Internet]. 2012 [cited 5 Jul 2020]. Available from: https://apps.who.int/iris/handle/10665/206910
17. Yeh CJ. Fatigue root fracture: a spontaneous root fracture in non-endodontically treated teeth. Br Dent J. 1997 Apr 12;182(7):261-6. [DOI:10.1038/sj.bdj.4809363] [PMID]
18. Nigam P, Srivastava AB. Betel chewing and dental decay. Fed Oper Dent. 1990 Aug;1(1):36-8.
19. Williams SA, Summers RM, Ahmed IH, Prendergast MJ. Caries experience, tooth loss and oral health related behaviours among Bangladeshi women resident in West Yorkshire, UK. Community Dent Health. 1996;13(3):150 6.
20. Li YC, Cheng AJ, Lee LY, Huang YC, Chang JT. Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation. J Cancer. 2019 Jul 8;10(17):4054-62. [DOI:10.7150/jca.29765] [PMID] [PMCID]
21. Reichart PA, Warnakulasuriya S. Oral lichenoid contact lesions induced by areca nut and betel quid chewing: a mini review. J Investig Clin Dent. 2012 Aug;3(3):163-6. [DOI:10.1111/j.2041-1626.2012.00130.x] [PMID]
22. Thomas SJ, Harris R, Ness AR, Taulo J, Maclennan R, Howes N, et al. Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence. Int J Cancer. 2008 Oct 15;123(8):1871-6. [DOI:10.1002/ijc.23739] [PMID]
23. Chen PH, Mahmood Q, Mariottini GL, Chiang TA, Lee KW. Adverse Health Effects of Betel Quid and the Risk of Oral and Pharyngeal Cancers. Biomed Res Int. 2017;2017:3904098. [DOI:10.1155/2017/3904098] [PMID] [PMCID]
24. Gupta B, Johnson NW. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS One. 2014 Nov 20;9(11):e113385. [DOI:10.1371/journal.pone.0113385] [PMID] [PMCID]
25. Prabhu RV, Prabhu V, Chatra L, Shenai P, Suvarna N, Dandekeri S. Areca nut and its role in oral submucous fibrosis. J Clin Exp Dent. 2014 Dec ;6(5):e569-75. [DOI:10.4317/jced.51318] [PMID] [PMCID]
26. Guha N, Warnakulasuriya S, Vlaanderen J, Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: a meta-analysis with implications for cancer control. Int J Cancer. 2014 Sep 15;135(6):1433-43. [DOI:10.1002/ijc.28643] [PMID]
27. Ahmad MS, Ali SA, Ali AS, Chaubey KK. Epidemiological and etiological study of oral submucous fibrosis among gutkha chewers of Patna, Bihar, India. J Indian Soc Pedod Prev Dent. 2006 Jun;24(2):84-9. [DOI:10.4103/0970-4388.26022] [PMID]
28. Shirzaii M. Oral Submucous Fibrosis in a 15-year-old Boy: The First Case Report in Iran. Shiraz Univ Dent J. 2011;11:51-5.
29. Hussain A, Zaheer S, Shafique K. School-based behavioral intervention to reduce the habit of smokeless tobacco and betel quid use in high-risk youth in Karachi: A randomized controlled trial. PLoS One. 2018 Nov 2;13(11):e0206919. [DOI:10.1371/journal.pone.0206919] [PMID] [PMCID]
30. Nagpal R, Nagpal N, Mehendiratta M, Marya CM, Rekhi A. Usage of betel quid, areca nut, tobacco, alcohol and level of awareness towards their adverse effects on health in a north Indian rural population. Oral Health Dent Manag. 2014 Mar;13(1):81-6.
31. Guo J, Xie H, Mao SH, Liang M, Wu H. Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta‐analysis of randomized controlled clinical trials. J Otolaryngol Head Neck Surg. 2020;49(4):311-19. [DOI:10.1111/jop.13009] [PMID]
32. Rao NR, Villa A, More CB, Jayasinghe RD, Ross Kerr A, Johnson NW. Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management. J Otolaryngol Head Neck Surg. 2020 Jan;49(3):1-11. [DOI:10.1186/s40463-020-0399-7] [PMID] [PMCID]
33. Tai YS, Liu BY, Wang JT, Sun A, Kwan HW, Chiang CP. Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis. J Oral Pathol Med. 2001 Nov;30(10):618-25. [DOI:10.1034/j.1600-0714.2001.301007.x] [PMID]
34. Azizi A, Dabirmoghadam P, Keykha F. Comparison of the Concentration of Salivary IL-8 in Patients with Oral Squamous Cell Carcinoma and Healthy Subjects . J Res Dentomaxillofac Sci. 2016; 1 (3) :28-32. [DOI:10.18869/acadpub.jrdms.1.3.28]
35. Ravikumar KK, Khan UN; Priyadarshini, Ramakrishnan K, Nachiappan S. Recurrent oral submucous fibrosis with nil mouth opening surgical management and reconstruction with bilateral nasolabial flap: A case report and review of literature. Indian J Dent Res. 2019 May-Jun;30(3):472-7. [DOI:10.4103/ijdr.IJDR_423_17] [PMID]
36. Javed F, Chotai M, Mehmood A, Almas K. Oral mucosal disorders associated with habitual gutka usage: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):857-64. [DOI:10.1016/j.tripleo.2009.12.038] [PMID]
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