Journal of Research in Dental
and Maxillofacial Sciences
Volume 11, Issue 2 (6-2026)
J Res Dent Maxillofac Sci 2026, 11(2): 126-135 |
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R Patil S, Daniel S, Veeraraghavan V P, Padmashali Jayappa N, Manyam R, A Rao K. Exploring Lactate Dehydrogenase as a Biomarker for Early Detection and Monitoring of Oral Submucous Fibrosis: A Preliminary Study. J Res Dent Maxillofac Sci 2026; 11 (2) :126-135
URL: http://jrdms.dentaliau.ac.ir/article-1-969-en.html
URL: http://jrdms.dentaliau.ac.ir/article-1-969-en.html
Santosh R Patil1 
, Shikhar Daniel *2 , Vishnu Priya Veeraraghavan3 , Nagarathna Padmashali Jayappa4 , Ravikanth Manyam5 , Krishna A Rao6
, Shikhar Daniel *2 , Vishnu Priya Veeraraghavan3 , Nagarathna Padmashali Jayappa4 , Ravikanth Manyam5 , Krishna A Rao6
1- Department of Oral Medicine and Radiology, Chhattisgarh Dental College and Research Institute, Chhattisgarh, India
2- Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India ,shikhardaniel555@gmail.com
3- Centre of Molecular Medicine and Diagnostics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
4- Department of Pediatric Dentistry, Chhattisgarh Dental College and Research Institute, Chhattisgarh
5- Department of Oral Pathology, Vishnu Dental College, Bhimavaram
6- Department of Oral Pathology JSS Dental College & Hospital, Mysuru
2- Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India ,
3- Centre of Molecular Medicine and Diagnostics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
4- Department of Pediatric Dentistry, Chhattisgarh Dental College and Research Institute, Chhattisgarh
5- Department of Oral Pathology, Vishnu Dental College, Bhimavaram
6- Department of Oral Pathology JSS Dental College & Hospital, Mysuru
Abstract: (13 Views)
Background and Aim: This study compared the serum and salivary lactate dehydrogenase (LDH) levels in patients with oral submucous fibrosis (OSMF) and healthy controls, and assessed their potential as biomarkers for OSMF diagnosis, and monitoring its progression.
Materials and Methods: This case-control study involved 50 OSMF patients and 50 age- and sex-matched healthy controls. Serum and salivary LDH levels were measured using standard laboratory techniques. Clinical staging of OSMF was performed based on the severity of symptoms, and the relationship between LDH levels and disease stage was analyzed using statistical methods. Descriptive and inferential statistics including t-test, ANOVA, and correlation coefficients based on data distribution were used to assess the association between LDH levels and OSMF clinical features (alpha=0.05).
Results: OSMF patients showed significantly higher serum LDH levels (225.4±58.2 U/L) than healthy controls (187.6±42.4 U/L; P=0.0004). They also showed significantly higher salivary LDH levels (180.3±53.1 U/L) compared to controls (148.2±37.9 U/L; P=0.0006). A strong positive correlation was found between serum LDH levels and clinical stage of OSMF (r=0.65, P<0.001), while a moderate inverse correlation was observed between salivary LDH levels and mouth opening (r=-0.48, P<0.001).
Conclusion: Both serum and salivary LDH levels were significantly elevated in patients with OSMF compared to healthy controls. Salivary LDH, in particular, demonstrated a strong association with clinical severity and disease stage, supporting its potential as an effective, non-invasive biomarker for OSMF diagnosis, and monitoring its progression.
Materials and Methods: This case-control study involved 50 OSMF patients and 50 age- and sex-matched healthy controls. Serum and salivary LDH levels were measured using standard laboratory techniques. Clinical staging of OSMF was performed based on the severity of symptoms, and the relationship between LDH levels and disease stage was analyzed using statistical methods. Descriptive and inferential statistics including t-test, ANOVA, and correlation coefficients based on data distribution were used to assess the association between LDH levels and OSMF clinical features (alpha=0.05).
Results: OSMF patients showed significantly higher serum LDH levels (225.4±58.2 U/L) than healthy controls (187.6±42.4 U/L; P=0.0004). They also showed significantly higher salivary LDH levels (180.3±53.1 U/L) compared to controls (148.2±37.9 U/L; P=0.0006). A strong positive correlation was found between serum LDH levels and clinical stage of OSMF (r=0.65, P<0.001), while a moderate inverse correlation was observed between salivary LDH levels and mouth opening (r=-0.48, P<0.001).
Conclusion: Both serum and salivary LDH levels were significantly elevated in patients with OSMF compared to healthy controls. Salivary LDH, in particular, demonstrated a strong association with clinical severity and disease stage, supporting its potential as an effective, non-invasive biomarker for OSMF diagnosis, and monitoring its progression.
Type of Study: Original article |
Subject:
Oral medicine
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