Volume 6, Issue 1 (3-2021)
J Res Dent Maxillofac Sci 2021, 6(1): 19-23 |
Back to browse issues page
1- Assistant Professor, Oral Medicine Dept, Dental School
2- Dental Student, Student Research Committee, Dental School
3- Social Determinants of Health Research Center, Department of Epidemiology & Statistics, Faculty of Medicine
4- Assistant Professor, Oral and Maxillofacial Pathology Dept, Dental School, Semnan University of Medical Sciences, Semnan, Iran. , dr.sh.sohanian@gmail.com
2- Dental Student, Student Research Committee, Dental School
3- Social Determinants of Health Research Center, Department of Epidemiology & Statistics, Faculty of Medicine
4- Assistant Professor, Oral and Maxillofacial Pathology Dept, Dental School, Semnan University of Medical Sciences, Semnan, Iran. , dr.sh.sohanian@gmail.com
Abstract: (1725 Views)
Background and Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disease, which is considered a precancerous condition. OLP is a multifactorial disease with no conclusive treatment. Timely diagnosis and treatment of oral lesions are necessary steps to prevent malignant transformations and severe complications of oral cancer. This study aimed to evaluate the frequency and severity of malignant transformations in OLP.
Materials and Methods: In this study, 2400 files of patients who presented to the Oral Medicine Department of the Dental School of Semnan University of Medical Sciences from 2013 to 2018 were evaluated. Data were statistically analyzed using SPSS.
Results: Forty patients (9 males and 31 females with the mean age of 45.2 years) were diagnosed with OLP (1.6%). The most common type of OLP was reticular (75%), and the least common was the ulcerative type. Since toluidine blue staining was positive for 4 patients (10%), a biopsy was done. The histopathological examinations showed one case with dysplasia (2.5%) and one case of carcinoma (2.5%).
Conclusion: According to the results, carcinoma and dysplasia can develop in OLP patients. Regular follow-ups are strongly recommended for timely diagnosis and treatment of malignant transformations.
Materials and Methods: In this study, 2400 files of patients who presented to the Oral Medicine Department of the Dental School of Semnan University of Medical Sciences from 2013 to 2018 were evaluated. Data were statistically analyzed using SPSS.
Results: Forty patients (9 males and 31 females with the mean age of 45.2 years) were diagnosed with OLP (1.6%). The most common type of OLP was reticular (75%), and the least common was the ulcerative type. Since toluidine blue staining was positive for 4 patients (10%), a biopsy was done. The histopathological examinations showed one case with dysplasia (2.5%) and one case of carcinoma (2.5%).
Conclusion: According to the results, carcinoma and dysplasia can develop in OLP patients. Regular follow-ups are strongly recommended for timely diagnosis and treatment of malignant transformations.
Type of Study: Original article |
Subject:
Oral medicine
References
1. [1] Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, et al. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S25.e1-12. [DOI:10.1016/j.tripleo.2006.11.001] [PMID]
2. [2] Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010 Jan-Feb;28(1):100-8. [DOI:10.1016/j.clindermatol.2009.03.004] [PMID]
3. [3] Gorouhi F, Solhpour A, Beitollahi JM, Afshar S, Davari P, Hashemi P, Nassiri Kashani M, Firooz A. Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus. J Am Acad Dermatol. 2007 Nov;57(5):806-13. [DOI:10.1016/j.jaad.2007.06.022] [PMID]
4. [4] Irani S, Monsef Esfahani A, Bidari Zerehpoush F. Detection of Helicobacter pylori in Oral Lesions. J Dent Res Dent Clin Dent Prospects. 2013 Fall;7(4):230-7.
5. [5] Ismail SB, Kumar SK, Zain RB. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007 Jun;49(2):89-106. [DOI:10.2334/josnusd.49.89] [PMID]
6. [6] Jones KB, Jordan R. White lesions in the oral cavity: clinical presentation, diagnosis, and treatment. Semin Cutan Med Surg. 2015 Dec;34(4):161-70. [DOI:10.12788/j.sder.2015.0180] [PMID]
7. [7] Glick M, William M. Burket's Oral Medicine. 12th ed. People's Medical Publishing House, USA, Ltd., 2015:105-9.
8. [8] van der Meij EH, Mast H, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients. Oral Oncol. 2007 Sep;43(8):742-8. [DOI:10.1016/j.oraloncology.2006.09.006] [PMID]
9. [9] González-Moles MÁ, Ruiz-Ávila I, González-Ruiz L, Ayén Á, Gil-Montoya JA, Ramos-García P. Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis. Oral Oncol. 2019 Sep;96:121-30. [DOI:10.1016/j.oraloncology.2019.07.012] [PMID]
10. [10] Irani S, Esfahani AM, Ghorbani A. Dysplastic change rate in cases of oral lichen planus: A retrospective study of 112 cases in an Iranian population. J Oral Maxillofac Pathol. 2016 Sep-Dec;20(3):395-9. [DOI:10.4103/0973-029X.190911] [PMID] [PMCID]
11. [11] Mardani M, Andisheh Tadbir A, Ahmadi R. The Prevalence of Malignant Transformation in Oral Lichen Planus in Two Main Centers in Shiraz (2006-2009). J Mazandaran Univ Med Sci. 2011;21(84):145-8.
12. [12] Pakfetrat A, Basir Shabestari S, Falaki F. Five year clinical and epidemiologic findings of oral lichen planus patients referred to oral medicine department of Mashhad dental school-Iran. J Mash Dent Sch 2008;32(3):195-8.
13. [13] Oliveira Alves MG, Almeida JD, Balducci I, Guimarães Cabral LA. Oral lichen planus: A retrospective study of 110 Brazilian patients. BMC Res Notes. 2010 Jun 3;3:157. [DOI:10.1186/1756-0500-3-157] [PMID] [PMCID]
14. [14] Tovaru S, Parlatescu I, Gheorghe C, Tovaru M, Costache M, Sardella A. Oral lichen planus: a retrospective study of 633 patients from Bucharest, Romania. Med Oral Patol Oral Cir Bucal. 2013 Mar 1;18(2):e201-6. [DOI:10.4317/medoral.18035] [PMID] [PMCID]
15. [15] Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014 Jan;145(1):45-56. [DOI:10.14219/jada.2013.10] [PMID]
16. [16] Guan G, Mei L, Polonowita A, Hussaini H, Seo B, Rich AM. Malignant transformation in oral lichen planus and lichenoid lesions: a 14-year longitudinal retrospective cohort study of 829 patients in New Zealand. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Oct;130(4):411-8. [DOI:10.1016/j.oooo.2020.07.002] [PMID]
17. [17] Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, Elsaadany BA, Ahmed EM. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017 May;68:92-102. [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
18. [18] Idrees M, Kujan O, Shearston K, Farah CS. Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria. J Oral Pathol Med. 2020 Jan 25. [DOI:10.1111/jop.12996] [PMID]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |