[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 2، شماره 3 - ( 7-1396 ) ::
جلد 2 شماره 3 صفحات 23-31 برگشت به فهرست نسخه ها
Clinical significance of salivary biomarkers in oral squamous cell carcinoma: a review
چکیده:   (258 مشاهده)
Background and Aim: Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all cancers worldwide, and if diagnosed early, it has a five-year survival rate of around 85%; however, a late diagnosis may decrease the survival rate to 50%. Aberrant expression of several genes is associated with the hallmarks of OSCC including uncontrolled cell proliferation, poor differentiation, invasion, metastasis, and angiogenesis. The potential of molecular biomarkers for the diagnosis, prognosis, or monitoring of the treatment efficacy in OSCC has been extensively explored during the last decades. This study aimed to review the significance of salivary biomarkers in the treatment outcome of OSCC.
Materials and Methods: The articles in scientific databases including Google Scholar, ScienceDirect, Medline, and PubMed, published between 2004 and 2017, were searched by using relevant keywords including OSCC, biomarkers, diagnosis, prognosis and treatment outcome. Thirty-four articles were reviewed in this study.
Results: According to the findings of the reviewed studies, several salivary biomarkers including subcutaneous adipose tissue (SAT), interleukin-8 (IL-8), Cyfra 21-1, 8-hydroxy-2-deoxyguanosine, malondialdehyde, lactate dehydrogenase (LDH), Annexin A8, ErbB2, carcinoembryonic antigen (CEA), C-reactive protein (CRP), and salivary proteomic biomarkers might be used as indicators for the detection of oral cancer and premalignant oral disease (PMOD) and as a potential marker in the prognosis of OSCC.
Conclusion: Salivary biomarker analysis seems to be a major advancement in the diagnosis of OSCC, and it is a fast-developing field in scientific research. The results indicate that salivary biomarkers can be useful diagnostic and prognostic tools in OSCC. 
متن کامل [PDF 2055 kb]   (125 دریافت)    
نوع مطالعه: Review article | موضوع مقاله: Oral pathology
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

کد امنیتی را در کادر بنویسید >


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Manzarpour M, Homaie M, Farhadi S. Clinical significance of salivary biomarkers in oral squamous cell carcinoma: a review. J Res Dentomaxillofac Sci. 2017; 2 (3) :23-31
URL: http://jrdms.dentaliau.ac.ir/article-1-172-fa.html

Clinical significance of salivary biomarkers in oral squamous cell carcinoma: a review. . 1396; 2 (3) :23-31

URL: http://jrdms.dentaliau.ac.ir/article-1-172-fa.html



دوره 2، شماره 3 - ( 7-1396 ) برگشت به فهرست نسخه ها
Journal of Research in Dental and Maxillofacial Sciences
Persian site map - English site map - Created in 0.052 seconds with 807 queries by yektaweb 3600