en Periodontology Periodontology Review article Review article <div style="text-align: justify;"><span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">Plasma is commonly known as the fourth state of matter. Cold atmospheric pressure plasma (CAPP) is a new, simple, and non-invasive approach that has become popular in various fields. Due to its potential antibacterial properties, it has become a widely used disinfectant in clinical science. It has even been employed for therapeutic purposes, such as cancer treatment and wound healing. This review aims to introduce CAPP as a new approach for management of periodontitis and peri-implantitis.</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods: </span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana="">A search was conducted in Scopus, PubMed and Web of Science databases for articles published between 2000 and 2023 using the keywords: &ldquo;plasma gases&rdquo;, &ldquo;non-thermal atmospheric pressure plasma&rdquo;, &ldquo;cold atmospheric pressure plasma&rdquo;, &ldquo;cold plasma&rdquo;, &ldquo;periodontal&rdquo;, &ldquo;periodontitis&rdquo; and &ldquo;peri-implantitis&rdquo;.</span></span>&nbsp;</span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results: </span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana="">The results showed that CAPP is effective for reducing the bacterial load and inflammation, modification of implant surfaces, promoting tissue regeneration, and improvement of clinical parameters. The use of CAPP in periodontal therapy and management of peri-implantitis is still in its early stages but studies have shown promising results.</span></span><span style="font-size:9.0pt"><span style="font-family:"Verdana",sans-serif"></span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">CAPP appears to be a promising adjuvant therapy for periodontitis and management of peri-implantitis. However, further clinical studies are needed to fully explore its potential and determine its effectiveness for this purpose.</span></span></span></span><br> &nbsp;</div> Peri-implantitis, Periodontitis, Plasma Gases 61 70 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-1286-2&slc_lang=en&sid=1 Hoda Ghodrati Hoda.gh95@gmail.com 100319475328460011826 100319475328460011826 No Department of Prosthodontics, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sara Monem Moharrer saramonem1378@gmail.com 100319475328460011827 0000000320391451 Yes Faculty of Dentistry, Tehran Medical Science Islamic Azad University, Tehran, Iran. Arash Azizi drarashazizi@yahoo.com 100319475328460011828 100319475328460011828 No Oral Medicine Department, Faculty of Dentistry, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Iran.