en Endodontics Endodontics Original article Original article <div style="text-align: justify;"><span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">Solubility of endodontic sealers should not exceed 3wt% in 24 hours. High solubility of sealers leads to gap formation and leakage through the canal wall and root filling material interface. This study aimed to compare the solubility of Endoseal and AH26 endodontic sealers. </span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods: </span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana="">In this in vitro, experimental study, 10 specimens with the same dimensions were fabricated from Endoseal and AH26 sealers (n=5 from each). After complete setting and initial weighing, each specimen was placed in a separate container containing 50 cc of distilled water and incubated at 37&deg;C. The weight loss of specimens was calculated using a digital scale after 1, 3, 7, and 30 days of immersion. Data were analyzed by SPSS version 23 using t-test and repeated measures ANOVA (alpha=0.05).&nbsp; </span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results: </span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana="">The overall mean weight of the two groups at different time points was not significantly different (P=0.453). Nevertheless, a significant weight change was observed in both the AH26 and Endoseal groups over time (P=0.0001). The solubility of AH26 increased while the solubility of Endoseal decreased with time (P=0.0001).</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">The solubility of both sealers was within the acceptable range according to the ANSI/ADA in the first 24 hours after setting. Both sealers experienced significant weight change over time, which was ascending in AH26 and descending in Endoseal. </span></span></span></span><br> &nbsp;</div> Epoxy Resin AH-26, Root Canal Therapy, Solubility 1 7 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-1268-1&slc_lang=en&sid=1 Nooshin Fakhari nooshin_67@ymail.com 100319475328460012134 0000000262954251 No Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Ali Reza Mirjani alirezamirjani.am@gmail.com 100319475328460012135 0009000217774072 No Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Abbas Bagheri abbas.bagheri75@yahoo.com 100319475328460012136 0000000194475936 Yes Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Jalil Modaresi jalil_modaresi@yahoo.com 100319475328460012137 0000000195300935 No Department of Endodontics, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran