en Periodontology Periodontology Review article Review article <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0cm 12px; text-align: justify;" valign="top"><span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b><b> </b><span style="font-size:9.0pt"><span style="font-family:" verdana="">With the advances in technology, the use of natural materials has broadened. </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">Acemannan is the main polysaccharide in aloe vera plant. It is a natural and biocompatible polymer with low toxicity. The acemannan monomers include mannose, glucose and galactose. Due to its biological properties, acemannan could be useful in bone regeneration.</span></span><span style="font-size:9.0pt"><span style="font-family:" verdana="">&nbsp; The aim of this study was to investigate the effect of acemannan/aloe vera on bone regeneration and extraction socket healing. &nbsp;</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods:</span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana=""> In this review article, an electronic search was conducted in PubMed and Scopus from 1996 to June 2022.<br> Relevant data based on clinical indications were extracted.</span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana=""> Twenty original articles, </span></span><span style="font-size:9.0pt"><span style="font-family:" verdana="">including </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">4 in vitro studies, 8 animal, and 8 human studies</span></span><span style="font-size:9.0pt"><span style="font-family:" verdana=""> were </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">reviewed</span></span><span style="font-size:9.0pt"><span style="font-family:" verdana="">. The inclusion criterion was articles that directly and originally evaluated the correlation of bone regeneration and acemannan/aloe vera.</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results</span></span></span></b><b><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b><b> </b><span style="font-size:9.0pt"><span style="font-family:" verdana="">Over 30 studies were found in this field by database searching. According to the results, the proposed items could be categorized into 3 major groups of </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">animals, human, and in vitro<br> studies. Animal studies were divided into two groups of bone defect regeneration and </span></span><span style="font-size:9.0pt"><span style="font-family:" verdana="">extraction </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">socket healing. Also, human studies were divided into two groups of bone defect regeneration and sinus floor elevation/guided bone regeneration surgeries.</span></span><span style="font-size:9.0pt"><span style="font-family:" verdana=""> All studies reported positive </span></span><span lang="EN" style="font-size:9.0pt"><span style="font-family:" verdana="">effect of Acemannan/aloe vera on bone healing and regeneration.</span></span><span style="font-size:9.0pt"><span style="font-family:"Verdana",sans-serif"></span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">Acemannan/aloe vera may be considered as a bioactive molecule due to induction and acceleration of bone formation. </span></span></span></span></td> </tr> </tbody> </table> </div> <br> <span style="font-size:14pt"><span style="line-height:normal"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span b="" style="font-family:" zar=""><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span> Acemannan, Aloe vera, Bone Regeneration, Tissue Engineering 226 235 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-1146-1&slc_lang=en&sid=1 Mohammadreza Tabatabaeian dr.taba7595@gmail.com 100319475328460012043 000000034256603X No School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran Vahid Esfahanian vahid.esfahanian@gmail.com 100319475328460012044 0000000260138832 Yes Department of Periodontology, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran