en Oral medicine Oral medicine Review article Review article <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0cm 12px; text-align: justify;" valign="top"><span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b><b> </b><span style="font-size:9.0pt"><span style="font-family:" verdana="">Oral giant cell fibroma (GCF) is a benign fibrous tumor<b> </b>that is histologically characterized by large, stellate, and mono- or multinucleated giant cells. GCF is an asymptomatic, sessile, or pedunculated exophytic lesion, usually smaller than 1 cm, with a smooth or papillary surface and the same color as the oral mucosa. The role of trauma in development of GCF has been contradictory. Knowledge about the characteristics of this lesion can help in diagnosis, treatment and follow-up of patients. &nbsp;</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Case Presentation:</span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana=""> This article describes five cases of GCF in Iranian patients, two of which were found in an uncommon location (buccal mucosa). Two were larger than usual (> 1 cm) and one had clinical manifestations resembling pyogenic granuloma. Patients were selected from two oral medicine centers.</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">To distinguish GCF from other types of irritation fibroma, size, location, and presence or absence of stimulating factors should not preclude diagnosis. The diagnosis is confirmed by detection of giant cells in histological examination. </span></span></span></span></td> </tr> </tbody> </table> </div> <div style="text-align: justify;"></div> Fibroma, Mouth, Oral Medicine 221 225 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-965-2&slc_lang=en&sid=1 Pegah Masannan Mozaffari mosannenp@mums.ac.ir 100319475328460012038 0000000309961193 No Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Nooshin Saeedi mahdi__sa1993@yahoo.com 100319475328460012039 0000000203009794 Yes Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mahdi Mohtasham mohtashamn@mums.ac.ir 100319475328460012040 0000000212624668 No Department of Oral and Maxillofacial Pathology, Mashhad University of Medical Sciences, Mashhad, Iran Farzaneh Khosravi 100319475328460012041 100319475328460012041 No Department of Cosmetic Medicine and Restorative Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Fatane Farjami 100319475328460012042 100319475328460012042 No Department of Orofacial medicine, Borås Hospital, Sweden