Journal of Research in Dental and Maxillofacial Sciences

en Association of Periodontitis and Aging-Related Diseases: A Review of Mechanistic Studies Periodontology Periodontology Review article Review article <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0cm 12px; text-align: justify;" valign="top">Background and Aim: Periodontitis, as the most prevalent cause of tooth loss, affects 20-50% of individuals throughout the world. One factor involved in the severity and incidence of periodontitis is aging, which is a substantial risk factor for mortality and morbidity. It is stated that some disorders are common in older population, like <a name="_Hlk102439922">cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer</a>’s disease. Understanding the changes related to aging may provide a better insight into age-related diseases. Hence, this study aimed to review and summarize evidence regarding periodontitis and aging-related disorders with a mechanistic insight.    Materials and Methods: Data were obtained from the scientific databases, including PubMed, Google Scholar, and Scopus in English between 1993 and 2021. Results: Cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease are associated with periodontitis directly or indirectly, and pro-inflammatory cytokines are the key mediators in such relationships. For instance, <a name="_Hlk102439976">interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 </a>have a substantial role in pathogenesis of periodontitis in the majority of such diseases. These agents, particularly IL-1β and TNF-α, can also lead to leukocyte migration and subsequently form reactive oxygen species (ROS), reactive nitrogen species, and matrix metalloproteinases (MMPs). Conclusion:  It seems that periodontitis is linked to aging-related diseases, namely cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease by the mediation of pro-inflammatory agents such as IL-1β, TNF-α, and IL-6.  </td> </tr> </tbody> </table> </div> Alzheimer’s Disease, Renal Failure, Osteoporosis, Cardiovascular Diseases, Periodontitis 62 70 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-908-1&slc_lang=en&sid=1 Mahnaz Gholami 100319475328460011394 100319475328460011394 No Department of Periodontics, Shiraz University of Medical Sciences, Shiraz, Iran Seyedeh Mohadeseh Asadinejad farhad0874@gmail.com 100319475328460011395 100319475328460011395 No Department of Periodontics, School of Dentistry, Isfahan University of Medi-cal Sciences, Isfahan, Iran Delara Kakavand 100319475328460011396 100319475328460011396 No Dental Clinic, Mazandaran University of Medical Sciences, Sari, Iran Pooya Jafari Doudaran 100319475328460011397 100319475328460011397 No Student Research Committee, Qom University of Medical Sciences, Qom, Iran Amir Hossein Fathi farhad20091367@gmail.com 100319475328460011398 100319475328460011398 Yes Dental Material Research Center and Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran