en Oral & maxillofacial surgery Oral & maxillofacial surgery Randomized Clinical Trial <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0in 12px; text-align: justify;" valign="top"> <p><span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b><b> </b><span style="font-size:9.0pt"><span style="font-family:" verdana="">Considering the side effects of high doses of opioids taken postoperatively for pain control, paracetamol and magnesium sulfate may be able to aid in pain control. This study assessed the effects of paracetamol and magnesium sulfate on the level of pain and opioid intake following orthognathic surgery. &nbsp;&nbsp;</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB" style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods</span></span></span></b><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana=""> In this double-blind randomized clinical trial, patients scheduled for bimaxillary orthognathic surgery were randomly assigned to two groups of 25. Group 1 patients received 1 g infusion of intravenous acetaminophen (paracetamol) administered within 20 minutes while group 2 patients received 50 mg/kg magnesium sulfate infusion one hour prior to completion of surgery. The patients were asked to express their level of pain prior to discharge from the recovery, and every 4 hours for 12 hours using a visual analog scale (VAS). Patients with pain score > 5 at any time received 30 mg pethidine. The total received dosage of pethidine postoperatively was recorded and those that received pethidine were not included in pain score analysis. Data were analyzed by generalized estimating equation (GEE), and Mann-Whitney U, Chi-square, and t-tests.</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results:</span></span></span></b><span style="font-size:9.0pt"><span style="font-family:" verdana=""> The pain score was not significantly different between the two groups at the time of recovery and 4 and 8 hours (P>0.05). The magnesium sulfate group had significantly lower pain score at 12 hours (P=0.009). The difference in pethidine dosage was not significant (P>0.05).</span></span></span></span><br> <span style="font-size:13pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana="">Both magnesium sulfate and paracetamol decreased postoperative pain and the need for opioid consumption, but magnesium sulfate was slightly more effective. </span></span></span></span></p> </td> </tr> </tbody> </table> </div> Acetaminophen, Magnesium Sulfate, Analgesics, Opioid, Orthognathic Surgery, Pain 241 248 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-893-1&slc_lang=en&sid=1 M Khalili khalilimahdi67@gmail.com 100319475328460010595 0000000199736859 No Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran K Farazmehr Koroushfaraz49@yahoo.com 100319475328460010596 0000000174741029 No Department of Anesthesiology and Critical Care, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran SH Shafaeefard Shahroozshafaeefard@gmail.com 100319475328460010597 0000000304510238 Yes Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran F Irani iranifatima71@gmail.com 100319475328460010598 000000027644819X No Private Dentistry practice, Tehran, Iran