en Oral pathology Oral pathology Review article Review article <pre data-placeholder="Translation" dir="rtl" id="tw-target-text"> </pre> <div style="text-align: justify;">Post-endodontic treatment pain is a major problem in dentistry. Around 80% of patients who present with preoperative pain due to endodontic treatment continue to experience the pain of some level following endodontic therapy. This pain, mostly linked to chronic inflammation, is due to bacterial toxins that signal the ingress of immune cells followed by the activation of various cytokines and inflammatory mediators. Countless classes of drugs have been studied to resolve this challenge. Glucocorticoids have been in use for more than fifty years owing to their potent anti-inflammatory effects. This paper aims to review the pharmacology and mechanism of actions of steroids as an intracanal medicament considering the indications, contraindications, and side effects.</div> Ledermix, Triamcinolone, Postoperative Pain, Hydrocortisone 47 51 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-810-1&slc_lang=en&sid=1 P Kar dr.priyankita.kar@gmail.com 100319475328460011017 100319475328460011017 Yes New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India. R Varghese drranavarghese@gmail.com 100319475328460011018 100319475328460011018 No New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India. N Agrawal agrawal.naina02@gmail.com 100319475328460011019 100319475328460011019 No New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India. H Jhaveri himanshi.smily@gmail.com 100319475328460011020 100319475328460011020 No New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India.