en Oral medicine Oral medicine Review article Review article <div style="text-align: justify;"><strong><span dir="LTR">Background and Aim: </span></strong><span dir="LTR">Chairside computer-aided design/computer-aided manufacturing (CAD/CAM) systems have become considerably more accurate, reliable, efficient, fast, and prevalent since 1985 when CEREC was introduced. The inceptive restorative material option for chairside CAD/CAM restorations was limited to ceramic blocks.</span> <span dir="LTR">Today, restorative material options have been multiplied and include metal alloys, ceramics, oxide ceramics, resins, and resin-matrix ceramics (RMC). This study aimed at making an overview of chairside CAD/CAM system materials and classifications.</span><br> <strong><span dir="LTR">Materials and Methods</span></strong><span dir="LTR">:<a name="_Hlk62628061"> An electronic search of the literature was carried out mainly through PubMed, ScienceDirect, Cochrane Library, and Google databases. The search aimed at collecting all the relevant English articles from 1965 to 2020.</a></span><br> <strong><span dir="LTR">Results: </span></strong><span dir="LTR">The analysis of the bond strength, fatigue resistance, flexural strength, elastic constants, microstructural characterization, accuracy, and clinical success of the materials showed variable outcomes. The marginal adaptation of resin ceramics has been reported to be comparable to that of lithium disilicate. It has been reported that the chairside CAD/CAM system using intraoral scanning is at least as accurate as the conventional method.</span><br> <strong><span dir="LTR">Conclusion: </span></strong><span dir="LTR">Chairside CAD/CAM restorations are fast, reliable, predictable, effective, patient-friendly, and cost-effective treatment options. Design software and intraoral scanners have made the treatment procedure simple. Chairside individualization of dental restorations could help improve patient satisfaction. However, considering the limited long-term clinical data, future studies need to address the long-term clinical performance of chairside CAD/CAM materials.</span></div> Ceramics, Computer-Aided Design, Surface Properties, Treatment Outcome 36 50 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-799-1&slc_lang=en&sid=1 S Eskandarion s.eskandarion@gmail.com 10031947532846008254 10031947532846008254 No Dental Material research center, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran M Neshandar s.eskandarion@gmail.com 10031947532846008255 10031947532846008255 No Prosthodontics Dept, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran R Rokhshad Rat_shad@yahoo.com 10031947532846008256 10031947532846008256 Yes Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran