en Oral & maxillofacial surgery Oral & maxillofacial surgery Case report <div style="text-align: justify;"><strong>Background: </strong>Keratocystic odontogenic tumors (KOT) have a high rate of recurrence, which is higher in patients diagnosed with Gorlin-Goltz syndrome (GGS). Adjunctive therapies, such as fixative chemical solutions, decrease the rate of recurrence after enucleation and peripheral ostectomy but have high morbidity rates. Topical 5-Fluorouracil (5-FU) has been suggested as a new therapy that provides a directed molecular approach to treatment. <span dir="RTL"></span><br> <strong>Case Presentation:</strong> This is a case report of GGS treated using topical 5-FU as an adjunctive material after enucleation and peripheral ostectomy. New bone formation sites were identified in the radiographic follow-up. The patient was followed up for 10 months regularly without any evidence of recurrence.<br> <strong>Conclusion: </strong>5-FlU is an effective and novel targeted treatment for KOTs. Topical application of 5-FU, following<br> enucleation and peripheral ostectomy, effectively treats syndromic KOTs, resulting in normal bony healing with no adverse local or systemic effects.</div> Odontogenic Tumors, Basal Cell Nevus Syndrome, Recurrence, 5-fluorouracil, salicylic acid drug combination [Supplementary Concept] 43 48 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-694-2&slc_lang=en&sid=1 hossein shiran hossein.shiran@gmail.com 10031947532846009775 10031947532846009775 Yes Postgraduate Student, Oral and Maxillofacial Surgery Dept, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran SH Shafaei Fard 10031947532846009776 10031947532846009776 No Associated Professor, Oral and Maxillofacial Surgery Dept , Faculty of Dentistry, Tehran Medical Sciences, S Hakimi 10031947532846009777 10031947532846009777 No Associated Professor , Oral and Maxillofacial Surgery Dept, Faculty of Dentistry,Medical Sciences University of Zahedan,Iran A Azari Pour Esfahani 10031947532846009778 10031947532846009778 No Postgraduate Student, Oral and Maxillofacial Surgery Dept,Faculty of Dentistry, Tehran Medical Sciences,