en Oral pathology Oral pathology Case report <strong>Background: </strong>Gingival overgrowth is a common clinical finding that most often represents reactive hyperplasia as a result of inflammatory gingival disease related to dental plaque. Irritation fibroma (IF), pyogenic granuloma (PG), peripheral ossifying fibroma (POF), and peripheral giant cell granuloma (PGCG) are non-neoplastic enlargements of the gingiva that are categorized as reactive hyperplastic lesions. Most of these lesions have a similar clinical appearance, i.e., a sessile or pedunculated nodule at the interdental papilla; the color varies from pale pink to red. All reactive gingival lesions show some variations in terms of gender, type, location, duration, and histologic features.<br> <strong>Case Presentation: </strong>Here, we present a case of PGCG in a 10-year-old male with its clinical presentations as well as radiological and histological features along with the management procedure.<br> <strong>Conclusion: </strong>Choice of treatment for our case was surgical excision, fluoride therapy, and oral hygiene maintenance. The patient remained tumor-free for 18 months and is still on regular follow-up. Giant Cell Lesion, Multinucleated Giant Cells, Osteoclast, Peripheral Giant Cell Granuloma, Maxilla 41 45 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-678-1&slc_lang=en&sid=1 P Moeiny pmoeiny@yahoo.com 10031947532846008950 10031947532846008950 No Assistant professor, Pediatric Dentistry Dept S Shabani sima.sh8869@gmail.com 10031947532846008951 10031947532846008951 Yes Postgraduate Student Pediatric Dentistry Dept M Vatankhah mona_vatan64@yahoo.com 10031947532846008952 10031947532846008952 No Postgraduate Student Pediatric Dentistry Dept A bakhshi 10031947532846008953 10031947532846008953 No Dentist, Vancouver, BC, Canada M Zameni 10031947532846008954 10031947532846008954 No Postgraduate Student Department of Oral and Maxillofacial Radiology