en Oral medicine Oral medicine Original article Original article <p align="right"></p> <p></p> <p><strong>Background</strong> <strong>and</strong> <strong>aim:</strong> Hyposalivation is one of the most common complications during menopause, which affects the quality of life. The aim of the present study was to assess the correlation between menopause and salivary flow rate.<br> <strong>Materials</strong> <strong>and</strong> <strong>methods:</strong> This historical-cohort study was conducted on 80 healthy women. Forty postmenopausal women were placed in the case group, while 40 premenopausal women were selected as the control group. The participants were selected from among non-smokers and non-alcoholics and had no systemic diseases. The saliva level of the participants was measured by using the Modified Schirmer&rsquo;s Test (MST) and modified Fox questionnaire. The participants were asked to sit upright, swallow their saliva and hold up their tongue. A strip was placed on the floor of the mouth, and the length of the wet and discolored area on the strip was measured after 3 minutes. Data were analyzed using SPSS 22 according to Mann-U-Whitney and Chi-square tests.<br> <strong>Results:</strong> According to the MST, the prevalence of hyposalivation was 35% in premenopausal women and 65% in postmenopausal women, with a statistically significant difference between the two groups (P<0.001). According to the modified Fox questionnaire, the prevalence of normal salivary flow and mild xerostomia in premenopausal women was 90%, while this rate was equal to 62.5% in postmenopausal women. The prevalence of severe xerostomia was 15% in postmenopausal women, while none of the premenopausal subjects had severe xerostomia. The incidence of hyposalivation in postmenopausal women is significantly higher than that in premenopausal women (P<0.005).<br> <strong>Conclusion:</strong> It seems that the unstimulated salivary flow rate decreases after menopause.<br> &nbsp;</p> Hyposalivation, Menopause, Xerostomia 16 21 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-575-1&slc_lang=en&sid=1 B Hosseinimehvar bahar_mehvar@yahoo.com 10031947532846009866 10031947532846009866 Yes Postgraduate Student,Oral Medicine Dept, Dental Branch of Tehran, Islamic Azad University,Tehran, Iran A Alaee ngln2006@yahoo.com 10031947532846009867 10031947532846009867 No Assistant professor, Oral medicine Dept, Member of Dental Material Research Center, Dental Branch of Tehran, Islamic Azad University,Tehran,Iran A Azizi drarashazizi@yahoo.com 10031947532846009868 10031947532846009868 No professor, Oral Medicine Dept, Member of Dental Implant Research Center, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran. N Shafizadeh Shafie zadeh @yahoo.com 10031947532846009869 10031947532846009869 No Assistant professor,Pediatric dentistry Dep, Dental Branch, Islamic Azad University, Tehran, Iran