fa Oral medicine Oral medicine Original article Original article <p style="margin: 0cm 0cm 8pt;"><b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">Background and aim: </font></span></b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">oral cancer is one of the most common cancers of the head and neck. Considering the high prevalence and mortality percentage of oral cancer and the significant advances in immunology and identification of different cytokines, the aim of the present study was to compare the concentration of IL₈</font><font color="#000000"> in saliva of patients with oral squamous cell carcinoma (OSCC) and healthy subjects.</font></span></p> <p style="margin: 0cm 0cm 8pt;"><b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">Materials and methods: </font></span></b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">in this case-control study, 20 individuals with a definite histopathology diagnosis of OSCC were selected as the case group and 20 healthy subjects were selected as the control group. The two groups were matched according to age, gender, cigarette smoking and alcohol consumption, medication consumption, periodontal disease (average CAL in first molars) and absence of systemic diseases. 5 ml of unstimulated whole saliva sample was collected with spitting method from each subject and the concentrations of salivary IL₈</font><font color="#000000"> were compared between the two groups. Linear regression and t-test were used for statistical analysis.</font></span></p> <p style="margin: 0cm 0cm 8pt;"><b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">Results:</font></span></b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000"> the concentration of IL₈</font><font color="#000000"> equaled 741.82</font></span><font color="#000000"><span calibri="" dir="LTR" style="line-height: 107%; font-family:;">&plusmn;</span><span calibri="" dir="LTR" style="line-height: 107%; font-family:;">722.81 pg/ml in the case group and 341.25</span><span calibri="" dir="LTR" style="line-height: 107%; font-family:;">&plusmn;</span></font><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">313.52 pg/ml in the control group and Mann-U-Whitney test showed that the concentration of IL₈</font><font color="#000000"> in patients with OSCC is higher than that in the control subjects and this difference is significant. (p=0.049) According to regression equation, IL</font>_{<font color="#000000">8</font>}<font color="#000000"> has a significant correlation with tumor size index (T). (p=0.011)</font></span></p> <p style="margin: 0cm 0cm 8pt;"><b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000">Conclusion:</font></span></b><span calibri="" dir="LTR" style="line-height: 107%; font-family:;"><font color="#000000"> the results of this study showed that the concentrations of salivary IL₈</font><font color="#000000"> were significantly different between the patients with OSCC and healthy subjects (p=0.049) and the concentration of IL</font>_{<font color="#000000">8</font>}<font color="#000000"> has a significant correlation with tumor size (T).</font></span></p> Interleukin 8, oral squamous cell carcinoma, saliva 28 32 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-325-4&slc_lang=fa&sid=1 A Azizi drarashazizi@yahoo.com 100319475328460010691 100319475328460010691 Yes Professor, Oral Medicine Dept, Dental Branch of Tehran, Islamic Azad University,Tehran, Iran P Dabirmoghadam 100319475328460010692 100319475328460010692 No Assistant professor, Otolaryngology Research center, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, IranTehran University of Medical Sciences, Tehran, Iran F Keykha 100319475328460010693 100319475328460010693 No Tehran