en Restorative Dentistry Restorative Dentistry Original article Original article <div style="text-align: justify;"><span style="font-size:13pt"><span style="line-height:109%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></span></b><b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana="">Composite resins are widely used in pediatric dentistry, but their color stability may be affected by medications and drinks. Since packable and bulk-fill composites differ in composition, this study aimed to compare their color stability after exposure to commonly consumed pediatric medications and drinks. &nbsp;</span></span></span>&nbsp;</span></span></span><br> <span style="font-size:13pt"><span style="line-height:109%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana="">In this in vitro study, disc-shaped specimens were fabricated from a packable and a bulk-fill composite resin (n=64 from each). After initial spectrophotometric color assessment, the discs underwent pH-cycling. Next, each group was divided into 8 subgroups (n=8) for immersion in distilled water (control), orange juice, chocolate milk, amoxicillin, metronidazole, acetaminophen, iron drop, and multi-vitamin syrup for 2 minutes every 8 hours for one week. The color of the specimens was then assessed again spectrophotometrically, and their color change (&Delta;E) was calculated. Data were analyzed by t-test, one-way ANOVA, and Tukey&rsquo;s test (alpha=0.05). </span></span></span>&nbsp;&nbsp;</span></span></span><br> <span style="font-size:13pt"><span style="line-height:109%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#0e101a">The two composite types had no significant difference in &Delta;E (P=0.733). The discoloration caused by metronidazole, amoxicillin, iron drop, and multivitamin syrup was clinically unacceptable (> 3 units). The discoloration caused by different materials was significantly different within each of the two composite groups (P=0.001), such that metronidazole yielded the highest, and distilled water yielded the lowest &Delta;E.</span></span></span></span><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:"Verdana",sans-serif"></span></span></span></span></span></span><br> <span style="font-size:13pt"><span style="line-height:109%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:109%"><span style="font-family:" verdana=""><span style="color:#0e101a">The research results showed that both packable and bulk-fill composite resins experienced comparable discoloration after exposure to different materials, with no significant difference between the two composite types. The results also showed that metronidazole produced the highest discoloration, while distilled water caused the lowest. </span></span></span></span>&nbsp;</span></span></span><br> &nbsp;</div> Acetaminophen, Amoxicillin, Color, Composite Resins, Metronidazole 57 65 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-2242-1&slc_lang=en&sid=1 Zohre Sadat Hosseinipour zohreshosseinipour@gmail.com 100319475328460016499 100319475328460016499 No Department of Pediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. Milad Bozhneh Miladbozhneh@gmail.com 100319475328460016500 100319475328460016500 No Dentist, Private Practice, Tehran, Iran Zahra Hosseini zhosseini@tums.ac.ir 100319475328460016501 100319475328460016501 Yes Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran