AU - shiran, hossein AU - Shafaei Fard, SH AU - Hakimi, S AU - Azari Pour Esfahani, A TI - Use of Topical 5-Fluorouracil for Keratocystic Odontogenic Tumors of Gorlin-Goltz Syndrome as a New Targeted Therapy: A Case Report and Review of Literature PT - JOURNAL ARTICLE TA - J-Res-Dent-Maxillofac-Sci JN - J-Res-Dent-Maxillofac-Sci VO - 4 VI - 4 IP - 4 4099 - http://jrdms.dentaliau.ac.ir/article-1-255-en.html 4100 - http://jrdms.dentaliau.ac.ir/article-1-255-en.pdf SO - J-Res-Dent-Maxillofac-Sci 4 ABĀ  - Background: Keratocystic odontogenic tumors (KOT) have a high rate of recurrence, which is higher in patients diagnosed with Gorlin-Goltz syndrome (GGS). Adjunctive therapies, such as fixative chemical solutions, decrease the rate of recurrence after enucleation and peripheral ostectomy but have high morbidity rates. Topical 5-Fluorouracil (5-FU) has been suggested as a new therapy that provides a directed molecular approach to treatment. Case Presentation: This is a case report of GGS treated using topical 5-FU as an adjunctive material after enucleation and peripheral ostectomy. New bone formation sites were identified in the radiographic follow-up. The patient was followed up for 10 months regularly without any evidence of recurrence. Conclusion: 5-FlU is an effective and novel targeted treatment for KOTs. Topical application of 5-FU, following enucleation and peripheral ostectomy, effectively treats syndromic KOTs, resulting in normal bony healing with no adverse local or systemic effects. CP - IRAN IN - Islamic Azad University, Tehran, Iran LG - eng PB - J-Res-Dent-Maxillofac-Sci PG - 43 PT - Case report YR - 2019