Mohsen Barzegar, Hamidreza Ghadirian, Zahra Roustaeizade Shooroki , Mohammad Amin Yektaie, Adele Pouyafard,
Volume 9, Issue 3 (9-2024)
Background and Aim: This study aimed to compare the effects of Triadent (triamcinolone mucoadhesive paste) and Ora-Aid mucoadhesive patch on the severity of pain, burning sensation, and size of minor aphthous ulcers.
Materials and Methods: This double-blind clinical trial was conducted on 40 patients with minor aphthous ulcers. The patients were randomly assigned to two groups (n=20) to use Triadent paste or Ora-Aid mucoadhesive patch (3 times/day). The severity of pain and burning sensation of patients was quantified by a visual analog scale (VAS). Size of lesions was also measured before, and at 3, 5, and 7 days after the treatment by using a graded paper placed next to the lesions. Data were analyzed by the t-test and the Mann-Whitney test (alpha=0.05).
Results: The mean reduction in lesion diameter at 3 days (compared with baseline) was significantly greater in the Ora-Aid than the Triadent group (P=0.000). However, the mean reduction in lesion diameter at 5 and 7 days was significantly greater in the Triadent group (P=0.000). The mean reduction in the severity of pain and burning sensation was significantly greater in the Ora-Aid group than the Triadent group at 3, 5, and 7 days (P=0.000).
Conclusion: Both Triadent and Ora-Aid significantly decreased pain, burning sensation, and size of minor aphthous lesions. However, Triadent was significantly more effective for reduction of size of lesions while Ora-Aid was significantly more effective for reduction of pain and burning sensation.
