S Sadatmansouri, N Ayubianmarkazi, S Aghajeri, Mr Delaram, B Iranpour,
Volume 1, Issue 3 (7-2016)
Abstract
Background and aim: Several reports have been published on the successful application of various bone substitute materials (BSM). Appropriate physiologic and histologic characteristics and reactions of these materials against host cells are critically important. In this study, the biocompatibility of a new bone substitute material has been evaluated.
Materials and Methods: In this experimental In vitro study, the biocompatibility of silicate calcium phosphate, Bio-Oss and Osteon were compared by evaluation of cell viability and differentiation rate of human osteoblast-like cell line (SaOS-2). No graft material was used in the control group. Cell viability rate was evaluated by MTT test after 1, 3 and 14 days of incubation. Inverted Light Microscope and SEM were utilized for evaluation of cell morphology. MTT and cell morphology were analyzed by ANOVA test in all groups
Results: Cell viability of the control group equaled 0.453±0.016, while in the test groups it equaled 0.453±0.016 for Bio-Oss, 0.439±0.011 for Osteon and 0.425±0.026 for silicate calcium phosphate. There was no significant difference between the control and the test groups. Spindle form was the dominant SaOS-2 cell morphology in all groups.
Conclusion: This study showed that calcium silicate phosphate has appropriate biocompatibility comparable with that of Bio-Oss and Osteon.
S Sadatmansouri, Sh Moradi, B Iranpour,
Volume 5, Issue 4 (11-2020)
Abstract
Background and Aim: Research on reducing the symptoms and discomfort after periodontal surgery is a priority. This study aimed to evaluate the effect of cyanoacrylate adhesive on tissue healing after periodontal surgery.
Materials and Methods: In this split-mouth clinical trial, all patients who needed periodontal pocket removal surgery in two or more sextants were examined after receiving written informed consent. The mouth of each patient was randomly divided into control and case groups. Cyanoacrylate adhesive was used in the case group, and sutures were used in the control group to close the wound. Pain, plaque index of the surgical site, and tissue healing were evaluated in the first week of follow-up. The probing depth in the surgical site was assessed at the second follow-up (6 weeks after surgery). All the parameters were statistically analyzed by Mann-U-Whitney test.
Results: In the first week of follow-up, the level of pain was 4.7±1.34 in the control group and 4.4±1.68 in the case group with no statistically significant difference (P=0.2). The healing rate was 3.3±0.53 in the control group and 2.7±0.64 in the case group with no statistically significant difference (P=0.3). The plaque index in the first week of follow-up was 3.9±0.82 in the control group and 3.8±0.97 in the case group (P=0.2). The probing depth in the sixth week of follow-up was 2.5±0.67 in the control group and 2.8±0.6 in the case group (P=0.2).
Conclusion: Considering the results, it seems that cyanoacrylate adhesive can be a good alternative to sutures, especially when the patient cannot present for suture removal at the appointed time.
