en Oral medicine Oral medicine Review article Review article <div style="text-align: justify;"><span style="font-size:13pt"><span style="line-height:105%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Background and Aim</span></span></span></span></b><b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana=""><span style="color:#2e74b5">:</span></span></span></span></b> <span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana="">Nanotechnology has revolutionized dentistry with the introduction of nanobots. These microscopic devices have shown promising applications in diagnosis, treatment, and preventive dental care. The aim of this study was to explore the diverse applications of nanobots along with artificial intelligence (AI) in different dental specialties, highlighting their advantages, limitations, and future potential. &nbsp;</span></span></span>&nbsp;</span></span></span><br> <span style="font-size:13pt"><span style="line-height:105%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Materials and Methods: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana="">For this comprehensive literature review, a complete query was carried out in PubMed, Google Scholar, Embase, and Scopus databases, and the studies published during 2010-2025 were collected using the keywords &quot;Nanotechnology,&quot; &quot;Dentistry,&quot; &quot;Robotics,&quot; &quot;Nanoparticles,&quot; and &quot;Dental Materials.&quot; After applying appropriate inclusion and exclusion criteria, 113 English articles were selected and evaluated. </span></span></span>&nbsp;&nbsp;</span></span></span><br> <span style="font-size:13pt"><span style="line-height:105%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana=""><span style="color:#2e74b5">Results: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:" verdana=""><span style="color:#0e101a">Nanobots demonstrate significant potential across various dental disciplines. In endodontics, they enhance root canal disinfection; while, in periodontics, they facilitate biofilm disruption and tissue regeneration. Restorative dentistry benefits from their integration into filling materials, improving durability and functionality. Orthodontic applications include precisely guided tooth movements and real-time monitoring of the periodontal environment. In oral surgery, nanobots enable precise tissue manipulation and accelerated wound healing. Furthermore, they offer promising capabilities for early diagnosis and targeted drug delivery systems in oral medicine.</span></span></span></span><span style="font-size:9.0pt"><span style="line-height:105%"><span style="font-family:"Verdana",sans-serif"></span></span></span></span></span></span><br> <b><span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#2e74b5">Conclusion:</span></span></span></b> <span style="font-size:9.0pt"><span style="font-family:" verdana=""><span style="color:#0e101a">Nanobots hold transformative potential in various dental disciplines, offering innovative solutions for improved diagnosis, treatment precision, and patient care. However, further research is needed to address safety concerns, regulatory approvals, ethical issues, and cost-effectiveness before clinical integration. Advancements in nanotechnology and AI may pave the way for the widespread use of nanobots, revolutionizing modern dental practice</span></span></span></div> Dental Materials, Dentistry, Nanoparticles, Nanotechnology, Robotics 84 96 http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-844-3&slc_lang=en&sid=1 Kiarash Kiani kiarashkiani13131313@gmail.com 100319475328460016469 100319475328460016469 No Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Mona Saligheh Rad monasalighehrad@gmail.com 100319475328460016470 100319475328460016470 No Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Arash Azizi drarashazizi@yahoo.com 100319475328460016471 100319475328460016471 No Oral Medicine Department, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Kimia Ghods kimiaghods2@gmail.com 100319475328460016472 100319475328460016472 Yes Dental Material Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran