Journal of Research in Dental and Maxillofacial Sciences
J Res Dent Maxillofac Sci
Medical Sciences
http://jrdms.dentaliau.ac.ir
1
admin
2383-2754
10.61186/jrdms
en
jalali
1397
1
1
gregorian
2018
4
1
3
2
online
1
fulltext
en
Comparison of Expression of p53 and bcl-2 Markers in Oral Lichen Planus and Oral Squamous Cell Carcinoma
Original article
Original article
<strong><span dir="LTR">Background and Aim</span></strong><span dir="LTR">: It has been suggested that oral lichen planus (OLP) can be a potential premalignant lesion. Reports are also available on the role of bcl-2 and p53 proteins in malignant transformation of OLP into oral squamous cell carcinoma (OSCC). Due to controversies in these reports, the present study aimed to compare the expression of p53 and bcl-2 markers in OLP and OSCC.</span><br>
<strong><span dir="LTR">Materials and Methods:</span></strong><span dir="LTR"> In this experimental study, immunohistochemical (IHC) staining was performed on erosive OLP and well-differentiated OSCC samples using bcl-2 and p53 antibodies. One-thousand cells per slide were counted, and the results were reported as percentages. The results were scored, and Mann-Whitney U test was used to compare staining grades in the two lesions.</span><br>
<strong><span dir="LTR">Results: </span></strong><span dir="LTR">Twenty-two OLP and 25 OSCC samples with a mean age of 49.3±15.8 years were evaluated. Bcl-2 expression was reported to be 16.27±8.95% in OLP and 16.4±22.9% in OSCC. Expression of p53 was 30.86±28.26% in OLP and 49.6±29.6% in OSCC. The difference in bcl-2 expression </span><span dir="LTR">between</span><span dir="LTR"> the two lesions was not significant (P=0.266), whereas this difference was significant for p53 expression (P=0.02). The correlation coefficient between these two markers was reported to be 0.45 in OSCC and 0.1 in OLP.</span><br>
<strong><span dir="LTR">Conclusion:</span></strong><span dir="LTR"> According to the results, there was a significant difference in p53 expression between OLP and OSCC samples, whereas this difference was not significant for bcl-2. There was no significant association between the expressions of these two markers in the samples. Therefore, there does not seem to be a high malignancy potential for the studied OLP samples.</span>
لیکن پلان دهانی , اسکواموس سل کارسینومای دهانی, Bcl2 , P53
Oral Lichen Planus, Oral Squamous Cell Carcinoma, bcl-2, p53
37
45
http://jrdms.dentaliau.ac.ir/browse.php?a_code=A-10-326-8&slc_lang=en&sid=1
S
Farhadi
dr.sfarhadi@gmail.com
10031947532846008983
10031947532846008983
No
Assistant professor, Oral & Maxillofacial Pathology Dept, Dental Branch of Tehran,
F
Shahsavari
dr.f.shahsavari@gmail.com
10031947532846008984
10031947532846008984
Yes
Assistant professor, Oral & Maxillofacial pathology dept, Dental branch of Tehran,
K
Alf
10031947532846008985
10031947532846008985
No
Dentist