%0 Journal Article %A Sarkarat, F %A Vahdati, SA %A Mahaseni aghdam, HR %A Nematallahi, Z %A Farahmand, M %T Bone Repair via Osteon and Bio-Oss: A Comparative Histological and Histomorphometric Animal Study %J Journal of Research in Dental and Maxillofacial Sciences %V 5 %N 2 %U http://jrdms.dentaliau.ac.ir/article-1-271-en.html %R 10.29252/jrdms.5.2.26 %D 2020 %K Biocompatible Materials, Bio-Oss, Bone Grafting, Bone Formation, Bone Substitutes, Histology, Osteon, %X Background and Aim: Autogenous bone grafts are considered the gold standard although they have several disadvantages, leading to a search for suitable alternative graft biomaterials. This study evaluates the histological and histomorphometric properties of regenerated bone in defects in rabbits following the application of two commercially available xenografts (Bio-Oss and Osteon). Materials and Methods: This animal study was carried out on 14 New Zealand rabbit calvaria. Four 6.5-mm critical-size defect (CSD) models of bone regeneration were formed in each surgical site. The first defect was filled with Bio-Oss, the second with large Osteon (L-Osteon), the third with small Osteon (S-Osteon), and the last one remained unfilled (the control group). The cases were sacrificed. Bone forming properties (amount of new bone formation, inflammation, and foreign body reaction) were observed at 4- and 8-week intervals through histological and histomorphometric examinations. The Friedman test, Kruskal-Wallis test, and Wilcoxon test for multiple comparisons were used for data analysis. The level of statistical significance was set at 0.05. Results: There was no statistically significant difference for regenerated bone among the four groups (P>0.05). The L-Osteon site showed more inflammation and foreign body reaction compared to the other groups. Conclusion: The results of this study showed that Bio-Oss and Osteon appear to be highly biocompatible and osteoconductive and can thus successfully be used as bone substitutes in augmentation procedures. %> http://jrdms.dentaliau.ac.ir/article-1-271-en.pdf %P 26-33 %& 26 %! Bone Repair via Osteon and Bio-Oss %9 Original article %L A-10-560-3 %+ Assistant Prof, Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Research Center, Dental Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. %G eng %@ %[ 2020